Patterns and Correlates of Baseline Thiazide-Type Diuretic Prescription in the Systolic Blood Pressure Intervention Trial

Thiazides and thiazide-type diuretics are recommended as first-line agents for the treatment of hypertension, but contemporary information on their use in clinical practice is lacking. We examined patterns and correlates of thiazide prescription in a cross-sectional analysis of baseline data from pa...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2016-03, Vol.67 (3), p.550-555
Main Authors: Chang, Tara I, Evans, Gregory, Cheung, Alfred K, Cushman, William C, Diamond, Matthew J, Dwyer, Jamie P, Huan, Yonghong, Kitzman, Dalane, Kostis, John B, Oparil, Suzanne, Rastogi, Anjay, Roumie, Christianne L, Sahay, Rukmani, Stafford, Randall S, Taylor, Addison A, Wright, Jackson T, Chertow, Glenn M
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Blood Pressure - drug effects
Blood Pressure - physiology
Cross-Sectional Studies
Female
Follow-Up Studies
Humans
Hypertension - drug therapy
Hypertension - physiopathology
Male
Middle Aged
Prescription Drugs
Retrospective Studies
Sodium Chloride Symporter Inhibitors - therapeutic use
Systole
Treatment Outcome
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Summary:Thiazides and thiazide-type diuretics are recommended as first-line agents for the treatment of hypertension, but contemporary information on their use in clinical practice is lacking. We examined patterns and correlates of thiazide prescription in a cross-sectional analysis of baseline data from participants enrolled in the Systolic Blood Pressure Intervention Trial (SPRINT). We examined baseline prescription of thiazides in 7582 participants receiving at least 1 antihypertensive medication by subgroup, and used log-binomial regression to calculate adjusted prevalence ratios for thiazide prescription (versus no thiazide). Forty-three percent of all participants were prescribed a thiazide at baseline, but among participants prescribed a single agent, the proportion was only 16%. The prevalence of thiazide prescription differed significantly by demographic factors, with younger participants, women, and blacks all having higher adjusted prevalence of thiazide prescription than other corresponding subgroups. Participants in the lowest category of kidney function (estimated glomerular filtration rate
ISSN:0194-911X
1524-4563
DOI:10.1161/HYPERTENSIONAHA.115.06851