Gene Polymorphism Association with Type 2 Diabetes and Related Gene-Gene and Gene-Environment Interactions in a Uyghur Population

BACKGROUND We investigated the association between 8 single-nucleotide polymorphisms (SNPs) at 3 genetic loci (CDKAL1, CDKN2A/2B and FTO) with type 2 diabetes (T2D) in a Uyghur population. MATERIAL AND METHODS A case-control study of 879 Uyghur patients with T2D and 895 non-diabetic Uyghur controls...

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Bibliographic Details
Published in:Medical science monitor 2016-02, Vol.22, p.474-487
Main Authors: Xiao, Shan, Zeng, Xiaoyun, Fan, Yong, Su, Yinxia, Ma, Qi, Zhu, Jun, Yao, Hua
Format: Article
Language:English
Subjects:
Adult
Aged
Alleles
Alpha-Ketoglutarate-Dependent Dioxygenase FTO - genetics
Asian People - genetics
Case-Control Studies
China
Clinical Research
Diabetes Mellitus, Type 2 - genetics
Female
Gene-Environment Interaction
Genes, p16
Genetic Predisposition to Disease
Genotype
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide
Risk Factors
tRNA Methyltransferases - genetics
Young Adult
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Summary:BACKGROUND We investigated the association between 8 single-nucleotide polymorphisms (SNPs) at 3 genetic loci (CDKAL1, CDKN2A/2B and FTO) with type 2 diabetes (T2D) in a Uyghur population. MATERIAL AND METHODS A case-control study of 879 Uyghur patients with T2D and 895 non-diabetic Uyghur controls was conducted at the Hospital of Xinjiang Medical University between 2010 and 2013. Eight SNPs in CDKAL1, CDKN2A/2B and FTO were analyzed using Sequenom MassARRAY®SNP genotyping. Factors associated with T2D were assessed by logistic regression analyses. Gene-gene and gene-environment interactions were analyzed by generalized multifactor dimensionality reduction. RESULTS Genotype distributions of rs10811661 (CDKN2A/2B), rs7195539, rs8050136, and rs9939609 (FTO) and allele frequencies of rs8050136 and rs9939609 differed significantly between diabetes and control groups (all P0.05), rs7195539 distribution differed significantly in co-dominant and dominant models (P
ISSN:1234-1010
1643-3750
DOI:10.12659/MSM.895347