Assessment of PSA-Age volume score in predicting positive prostate biopsy findings in Turkey

• Published in: International Brazilian Journal of Urology 2015-10, Vol.41 (5), p.864-868
• Main Authors: Uçer, Oktay, Yücetaş, Uğur, Çelen, İlker, Toktaş, Gökhan, Müezzinoğlu, Talha
• Format: Article
• Language: English
• Subjects: Biopsy; Digital Rectal Examination; Original; Prostate; Prostate-Specific Antigen; Prostatic Neoplasms
• ISSN: 1677-5538; 1677-6119; 1677-5538; 1677-6119
• DOI: 10.1590/S1677-5538.IBJU.2014.0462

ABSTRACT Objectives: To evaluate PSA-age volume (AV) scores in predicting positive prostate biopsy findings in Turkey. Materials and Methods: PSA-AV was calculated by multiplying the patient's age by the prostate volume and dividing it by the PSA level. Sensitivities and specificities of the PSA-AV were assessed by retrospective analysis of findings from 4,717 prostate biopsies. Results: The population's average age was 63.71±7.63 years, the mean PSA level was 9.73±17.01ng/mL, the mean prostate volume was 44.46±23.88 cm3. Of the 4,717 prostate biopsies, 1,171 biopsy specimens (24.8%) were positive for prostate cancer. A PSA-AV score of 700 had a sensitivity and specificity of 95% and 15%, respectively. These values were similar to the sensitivity and specificity for a PSA cut-off of 4ng/mL (94% and 13%, respectively). Although the sensitivity of a PSA-AV cut-off of 700 in patients over 60 years was similar to the PSA cut-off of 4ng/mL and the age-adjusted PSA, in patients