The relationship between serum fatty-acid binding protein 4 level and lung function in Korean subjects with normal ventilatory function

• Published in: BMC pulmonary medicine 2016-02, Vol.16 (34), p.34-34, Article 34
• Main Authors: Park, Hye-Jeong, Park, Se Eun, Park, Cheol-Young, Lim, Seong Yong, Lee, Won-Young, Oh, Ki-Won, Park, Sung-Woo, Rhee, Eun-Jung
• Format: Article
• Language: English
• Subjects: Adult; Analysis; Asian Continental Ancestry Group; Body Composition; Care and treatment; Complications and side effects; Enzyme-Linked Immunosorbent Assay; Enzymes; Fatty Acid-Binding Proteins - blood; Female; Forced Expiratory Volume; Humans; Influence; Insulin Resistance; Lung - physiology; Lung - physiopathology; Lung Diseases - blood; Lung Diseases - physiopathology; Male; Metabolic diseases; Middle Aged; Odds Ratio; Protein binding; Pulmonary Ventilation - physiology; Pulmonology; Republic of Korea; Spirometry; Vital Capacity
• ISSN: 1471-2466; 1471-2466
• DOI: 10.1186/s12890-016-0190-8

The aim of this study was to assess the association of lung function with serum fatty-acid binding protein 4 (FABP4) in apparently healthy Korean adults. In 495 participants in a health screening program, Force Exploratory Volume (FEV) 1 and Forced Vital Capacity (FVC) were assessed with standard spirometry. Subjects with obstructive (n = 19) and restrictive (n = 45) lung function were excluded from the analysis. Serum FABP4 level was measured by enzyme-linked immunosorbent assay and transformed into Ln(FABP4). 431 subjects with normal ventilator function (72.4% men, mean age 41 years) were included in the final analysis. Mean Ln(FABP4) significantly decreased in subjects from 1(st) quartile to 4(th) quartile of FVC (p = 0.008). Ln(FABP4) did not show significant differences across the quartile groups of FEV1. The odds ratio (OR) of being in the lowest quartile of FVC was 2.704 in subject with 3(rd) tertile of Ln(FABP4) after full adjustment for confounding variables {95% confidence interval (CI) 1.397 ~ 5.357}. OR of being in the lowest quartile of FEV1 was 1.822 (95% CI 1.021 ~ 3.298) in subjects with 3(rd) tertile of Ln(FABP4) after adjustment of age and sex, which was attenuated after full adjustment for confounding variables. Increased FABP4 level showed increased risk for reduced lung function in subjects with normal ventilatory function.