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Nanoliposomes protect against human arteriole endothelial dysfunction induced by β-amyloid peptide
We tested whether nanoliposomes containing phosphatidylcholine, cholesterol and phosphatidic acid (NLPA) prevent β-amyloid 1-42 (Aβ42) fibrillation and Aβ42-induced human arteriole endothelial dysfunction. NLPA abolished Aβ42 fibril formation (thioflavin-T fluorescence/electron microscopy). In ex-vi...
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| Published in: | Journal of cerebral blood flow and metabolism 2016-02, Vol.36 (2), p.405-412 |
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| Main Authors: | , , , , , , , , , , |
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| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c537t-4715c20f44a1d6c84d4a4f55a2f38a15c6f7ade6747a0fa7bd2450acbaa89d9c3 |
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| cites | cdi_FETCH-LOGICAL-c537t-4715c20f44a1d6c84d4a4f55a2f38a15c6f7ade6747a0fa7bd2450acbaa89d9c3 |
| container_end_page | 412 |
| container_issue | 2 |
| container_start_page | 405 |
| container_title | Journal of cerebral blood flow and metabolism |
| container_volume | 36 |
| creator | Truran, Seth Weissig, Volkmar Madine, Jillian Davies, Hannah A Guzman-Villanueva, Diana Franco, Daniel A Karamanova, Nina Burciu, Camelia Serrano, Geidy Beach, Thomas G Migrino, Raymond Q |
| description | We tested whether nanoliposomes containing phosphatidylcholine, cholesterol and phosphatidic acid (NLPA) prevent β-amyloid 1-42 (Aβ42) fibrillation and Aβ42-induced human arteriole endothelial dysfunction. NLPA abolished Aβ42 fibril formation (thioflavin-T fluorescence/electron microscopy). In ex-vivo human adipose and leptomeningeal arterioles, Aβ42 impaired dilator response to acetylcholine that was reversed by NLPA; this protection was abolished by L-NG-nitroarginine methyl ester. Aβ42 reduced human umbilical vein endothelial cell NO production that was restored by NLPA. Nanoliposomes prevented Aβ42 amyloid formation, reversed Aβ42-induced human microvascular endothelial dysfunction and may be useful in Alzheimer’s disease. |
| doi_str_mv | 10.1177/0271678X15610134 |
| format | article |
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NLPA abolished Aβ42 fibril formation (thioflavin-T fluorescence/electron microscopy). In ex-vivo human adipose and leptomeningeal arterioles, Aβ42 impaired dilator response to acetylcholine that was reversed by NLPA; this protection was abolished by L-NG-nitroarginine methyl ester. Aβ42 reduced human umbilical vein endothelial cell NO production that was restored by NLPA. Nanoliposomes prevented Aβ42 amyloid formation, reversed Aβ42-induced human microvascular endothelial dysfunction and may be useful in Alzheimer’s disease.</description><identifier>ISSN: 0271-678X</identifier><identifier>EISSN: 1559-7016</identifier><identifier>DOI: 10.1177/0271678X15610134</identifier><identifier>PMID: 26661197</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Acetylcholine - antagonists & inhibitors ; Acetylcholine - pharmacology ; Adipose Tissue - blood supply ; Amyloid beta-Peptides ; Arterioles - pathology ; Cholesterol - administration & dosage ; Cholesterol - therapeutic use ; Endothelium, Vascular - pathology ; Humans ; In Vitro Techniques ; Liposomes - therapeutic use ; Male ; Meninges - blood supply ; Middle Aged ; Nanoparticles - therapeutic use ; NG-Nitroarginine Methyl Ester - pharmacology ; Nitric Oxide - biosynthesis ; Original ; Peptide Fragments ; Phosphatidic Acids - administration & dosage ; Phosphatidic Acids - therapeutic use ; Phosphatidylcholines - administration & dosage ; Phosphatidylcholines - therapeutic use ; Vascular Diseases - chemically induced ; Vascular Diseases - pathology ; Vascular Diseases - prevention & control ; Vasodilation - drug effects ; Vasodilator Agents - pharmacology</subject><ispartof>Journal of cerebral blood flow and metabolism, 2016-02, Vol.36 (2), p.405-412</ispartof><rights>The Author(s) 2015</rights><rights>The Author(s) 2015.</rights><rights>The Author(s) 2015 2015 International Society for Cerebral Blood Flow and Metabolism</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c537t-4715c20f44a1d6c84d4a4f55a2f38a15c6f7ade6747a0fa7bd2450acbaa89d9c3</citedby><cites>FETCH-LOGICAL-c537t-4715c20f44a1d6c84d4a4f55a2f38a15c6f7ade6747a0fa7bd2450acbaa89d9c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759678/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759678/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792,79235</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26661197$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Truran, Seth</creatorcontrib><creatorcontrib>Weissig, Volkmar</creatorcontrib><creatorcontrib>Madine, Jillian</creatorcontrib><creatorcontrib>Davies, Hannah A</creatorcontrib><creatorcontrib>Guzman-Villanueva, Diana</creatorcontrib><creatorcontrib>Franco, Daniel A</creatorcontrib><creatorcontrib>Karamanova, Nina</creatorcontrib><creatorcontrib>Burciu, Camelia</creatorcontrib><creatorcontrib>Serrano, Geidy</creatorcontrib><creatorcontrib>Beach, Thomas G</creatorcontrib><creatorcontrib>Migrino, Raymond Q</creatorcontrib><title>Nanoliposomes protect against human arteriole endothelial dysfunction induced by β-amyloid peptide</title><title>Journal of cerebral blood flow and metabolism</title><addtitle>J Cereb Blood Flow Metab</addtitle><description>We tested whether nanoliposomes containing phosphatidylcholine, cholesterol and phosphatidic acid (NLPA) prevent β-amyloid 1-42 (Aβ42) fibrillation and Aβ42-induced human arteriole endothelial dysfunction. NLPA abolished Aβ42 fibril formation (thioflavin-T fluorescence/electron microscopy). In ex-vivo human adipose and leptomeningeal arterioles, Aβ42 impaired dilator response to acetylcholine that was reversed by NLPA; this protection was abolished by L-NG-nitroarginine methyl ester. Aβ42 reduced human umbilical vein endothelial cell NO production that was restored by NLPA. Nanoliposomes prevented Aβ42 amyloid formation, reversed Aβ42-induced human microvascular endothelial dysfunction and may be useful in Alzheimer’s disease.</description><subject>Acetylcholine - antagonists & inhibitors</subject><subject>Acetylcholine - pharmacology</subject><subject>Adipose Tissue - blood supply</subject><subject>Amyloid beta-Peptides</subject><subject>Arterioles - pathology</subject><subject>Cholesterol - administration & dosage</subject><subject>Cholesterol - therapeutic use</subject><subject>Endothelium, Vascular - pathology</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Liposomes - therapeutic use</subject><subject>Male</subject><subject>Meninges - blood supply</subject><subject>Middle Aged</subject><subject>Nanoparticles - therapeutic use</subject><subject>NG-Nitroarginine Methyl Ester - pharmacology</subject><subject>Nitric Oxide - biosynthesis</subject><subject>Original</subject><subject>Peptide Fragments</subject><subject>Phosphatidic Acids - administration & dosage</subject><subject>Phosphatidic Acids - therapeutic use</subject><subject>Phosphatidylcholines - administration & dosage</subject><subject>Phosphatidylcholines - therapeutic use</subject><subject>Vascular Diseases - chemically induced</subject><subject>Vascular Diseases - pathology</subject><subject>Vascular Diseases - prevention & control</subject><subject>Vasodilation - drug effects</subject><subject>Vasodilator Agents - pharmacology</subject><issn>0271-678X</issn><issn>1559-7016</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqNkU-LFDEQxYMo7rh69yQ5euk16c6f7osgi7rCohcFb6EmqZ7J0p20SXphvpYfxM9khlkXFQRPdXi_elS9R8hzzi441_oVazVXuv_KpeKMd-IB2XAph0Yzrh6SzVFujvoZeZLzDWOs76R8TM5apRTng94Q-xFCnPwSc5wx0yXFgrZQ2IEPudD9OkOgkAomHyekGFwse5w8TNQd8rgGW3wM1Ae3WnR0e6A_vjcwH6boHV1wKd7hU_JohCnjs7t5Tr68e_v58qq5_vT-w-Wb68bKTpdGaC5ty0YhgDtle-EEiFFKaMeuh6qpUYNDpYUGNoLeulZIBnYL0A9usN05eX3yXdbtjM5iKAkmsyQ_QzqYCN78qQS_N7t4a4SWQ42pGry8M0jx24q5mNlni9MEAeOaTY2867uhFd1_oLWRniupKspOqE0x54Tj_UWcmWON5u8a68qL3z-5X_jVWwWaE5Bhh-YmrinUZP9t-BNnG6ld</recordid><startdate>20160201</startdate><enddate>20160201</enddate><creator>Truran, Seth</creator><creator>Weissig, Volkmar</creator><creator>Madine, Jillian</creator><creator>Davies, Hannah A</creator><creator>Guzman-Villanueva, Diana</creator><creator>Franco, Daniel A</creator><creator>Karamanova, Nina</creator><creator>Burciu, Camelia</creator><creator>Serrano, Geidy</creator><creator>Beach, Thomas G</creator><creator>Migrino, Raymond Q</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope><scope>5PM</scope></search><sort><creationdate>20160201</creationdate><title>Nanoliposomes protect against human arteriole endothelial dysfunction induced by β-amyloid peptide</title><author>Truran, Seth ; 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| identifier | ISSN: 0271-678X |
| ispartof | Journal of cerebral blood flow and metabolism, 2016-02, Vol.36 (2), p.405-412 |
| issn | 0271-678X 1559-7016 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4759678 |
| source | Sage Journals Online; PubMed Central |
| subjects | Acetylcholine - antagonists & inhibitors Acetylcholine - pharmacology Adipose Tissue - blood supply Amyloid beta-Peptides Arterioles - pathology Cholesterol - administration & dosage Cholesterol - therapeutic use Endothelium, Vascular - pathology Humans In Vitro Techniques Liposomes - therapeutic use Male Meninges - blood supply Middle Aged Nanoparticles - therapeutic use NG-Nitroarginine Methyl Ester - pharmacology Nitric Oxide - biosynthesis Original Peptide Fragments Phosphatidic Acids - administration & dosage Phosphatidic Acids - therapeutic use Phosphatidylcholines - administration & dosage Phosphatidylcholines - therapeutic use Vascular Diseases - chemically induced Vascular Diseases - pathology Vascular Diseases - prevention & control Vasodilation - drug effects Vasodilator Agents - pharmacology |
| title | Nanoliposomes protect against human arteriole endothelial dysfunction induced by β-amyloid peptide |
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