Establishment and application of a new diagnostic definition of metabolic syndrome in the Shantou region of southern China

The existing definitions of metabolic syndrome (MetS) may not be fully appropriate for the Shantou population because of ethnic and regional differences. We sought to establish a 95% multivariate medical reference range (MMRR) model for diagnosing MetS in Shantou adults and to evaluate the prevalenc...

Full description

Saved in:
Bibliographic Details
Published in:Scientific reports 2016-02, Vol.6 (1), p.22210-22210, Article 22210
Main Authors: Ding, Zan, Pi, Fuhua, Zhang, Shengchao, Dong, Wenya, Wen, Ye, Wu, Jiang, Zhang, Qingying
Format: Article
Language:English
Subjects:
692/308/174
692/499
692/699/317
Adult
Algorithms
Biomarkers
Blood pressure
China - epidemiology
Cholesterol
Diabetes mellitus
Fasting
Female
Humanities and Social Sciences
Humans
Low density lipoprotein
Male
Metabolic syndrome
Metabolic Syndrome - diagnosis
Metabolic Syndrome - epidemiology
Middle Aged
Models, Theoretical
multidisciplinary
Population Surveillance
Prevalence
Science
Triglycerides
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The existing definitions of metabolic syndrome (MetS) may not be fully appropriate for the Shantou population because of ethnic and regional differences. We sought to establish a 95% multivariate medical reference range (MMRR) model for diagnosing MetS in Shantou adults and to evaluate the prevalence of MetS by the MMRR, JCDCG (the Chinese Guidelines) and International Diabetes Federation (IDF) criteria. A total of 4,580 participants were recruited in Shantou, southern China. We developed a MMRR model based on the combinatorial indicatrixes method for three categorized indicatrixes. According to the developed MMRR criteria, men (women) in Shantou have MetS by meeting 3 or more of the following: waist circumference ≥89 (81) cm; triglycerides level ≥1.73 (1.64) mmol/L; high-density lipoprotein cholesterol level ≤1.07 (1.05) mmol/L; blood pressure ≥138/89 (136/85) mmHg; and fasting plasma glucose ≥5.8 (5.7) mmol/L. The agreement of the MMRR with JCDCG and IDF criteria was “substantial” (both κ > 0.68), but the recommended reference values and proportion of individual components of MetS defined by the 3 criteria differed. The population-based MMRR criteria may be appropriate for diagnosing MetS in Shantou population and the model might be useful for generalization to other geographic regions.
ISSN:2045-2322
2045-2322
DOI:10.1038/srep22210