Origins of cardiac fibroblasts

Abstract Cardiac fibroblasts produce the extracellular matrix (ECM) scaffold within which the various cellular components of the heart are organized. As well as providing structural support, it is becoming evident that the quality and quantity of ECM is a key factor for determining cardiac cell beha...

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Bibliographic Details
Published in:Journal of molecular and cellular cardiology 2016-02, Vol.91, p.1-5
Main Authors: Moore-Morris, Thomas, Cattaneo, Paola, Puceat, Michel, Evans, Sylvia M
Format: Article
Language:English
Subjects:
Animals
Basic Helix-Loop-Helix Transcription Factors - genetics
Basic Helix-Loop-Helix Transcription Factors - metabolism
Biomarkers - metabolism
Cardiac lineage
Cardiovascular
Cell Lineage - physiology
Collagen Type I - genetics
Collagen Type I - metabolism
Discoidin Domain Receptors
Extracellular Matrix - metabolism
Fibroblast
Fibroblast markers
Fibroblasts - metabolism
Fibroblasts - pathology
Fibrosis
Gene Expression
Heart Failure - genetics
Heart Failure - metabolism
Heart Failure - pathology
Humans
Hypertrophy
Myocardial infarction
Myocardium - metabolism
Myocardium - pathology
Receptor Protein-Tyrosine Kinases - genetics
Receptor Protein-Tyrosine Kinases - metabolism
Receptor, Platelet-Derived Growth Factor beta - genetics
Receptor, Platelet-Derived Growth Factor beta - metabolism
Receptors, Mitogen - genetics
Receptors, Mitogen - metabolism
T-Box Domain Proteins - genetics
T-Box Domain Proteins - metabolism
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Summary:Abstract Cardiac fibroblasts produce the extracellular matrix (ECM) scaffold within which the various cellular components of the heart are organized. As well as providing structural support, it is becoming evident that the quality and quantity of ECM is a key factor for determining cardiac cell behavior during development and in pathological contexts such as heart failure involving fibrosis. Cardiac fibroblasts have long remained a poorly characterized cardiac lineage. Well characterized markers are now paving the way for a better understanding of the roles of these cells in various developmental and disease contexts. Notably, the relevance of processes including endothelial-tomesenchymal transition and the recruitment of circulating fibroblast progenitors in heart failure has been challenged. This review describes the latest findings on cardiac fibroblast markers and developmental origins, and discusses their importance in myocardial remodeling. Effective modulation of cardiac fibroblast activity would likely contribute to successful treatment of various cardiac disorders.
ISSN:0022-2828
1095-8584
DOI:10.1016/j.yjmcc.2015.12.031