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Unique Loss of the PYHIN Gene Family in Bats Amongst Mammals: Implications for Inflammasome Sensing
Recent genomic analysis of two bat species ( Pteropus alecto and Myotis davidii ) revealed the absence of the PYHIN gene family. This family is recognized as important immune sensors of intracellular self and foreign DNA and activators of the inflammasome and/or interferon pathways. Further assessme...
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| Published in: | Scientific reports 2016-02, Vol.6 (1), p.21722-21722, Article 21722 |
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| creator | Ahn, Matae Cui, Jie Irving, Aaron T. Wang, Lin-Fa |
| description | Recent genomic analysis of two bat species (
Pteropus alecto
and
Myotis davidii
) revealed the absence of the PYHIN gene family. This family is recognized as important immune sensors of intracellular self and foreign DNA and activators of the inflammasome and/or interferon pathways. Further assessment of a wider range of bat genomes was necessary to determine if this is a universal pattern for this large mammalian group. Here we expanded genomic analysis of this gene family to include ten bat species. We confirmed the complete loss of this gene family, with only a truncated
AIM2
remaining in one species (
Pteronotus parnellii
). Divergence of the PYHIN gene loci between the bat lineages infers different loss-of-function histories during bat evolution. While all other major groups of placental mammals have at least one gene member, only bats have lost the entire family. This removal of inflammasome DNA sensors may indicate an important adaptation that is flight-induced and related, at least in part, to pathogen-host co-existence. |
| doi_str_mv | 10.1038/srep21722 |
| format | article |
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Pteropus alecto
and
Myotis davidii
) revealed the absence of the PYHIN gene family. This family is recognized as important immune sensors of intracellular self and foreign DNA and activators of the inflammasome and/or interferon pathways. Further assessment of a wider range of bat genomes was necessary to determine if this is a universal pattern for this large mammalian group. Here we expanded genomic analysis of this gene family to include ten bat species. We confirmed the complete loss of this gene family, with only a truncated
AIM2
remaining in one species (
Pteronotus parnellii
). Divergence of the PYHIN gene loci between the bat lineages infers different loss-of-function histories during bat evolution. While all other major groups of placental mammals have at least one gene member, only bats have lost the entire family. This removal of inflammasome DNA sensors may indicate an important adaptation that is flight-induced and related, at least in part, to pathogen-host co-existence.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep21722</identifier><identifier>PMID: 26906452</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/181/2474 ; 631/208/182 ; Animals ; Base Sequence ; Bats ; Chiroptera - genetics ; Conserved Sequence ; Deoxyribonucleic acid ; Divergence ; DNA ; Evolution, Molecular ; Genetic Loci ; Genomes ; Genomic analysis ; Humanities and Social Sciences ; Inflammasomes ; Inflammasomes - physiology ; Interferon ; Mammals ; multidisciplinary ; Pyrin Domain ; Science ; Science (multidisciplinary) ; Sensors ; Sequence Analysis, DNA ; Species</subject><ispartof>Scientific reports, 2016-02, Vol.6 (1), p.21722-21722, Article 21722</ispartof><rights>The Author(s) 2016</rights><rights>Copyright Nature Publishing Group Feb 2016</rights><rights>Copyright © 2016, Macmillan Publishers Limited 2016 Macmillan Publishers Limited</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c504t-e672a1595ea38778306eb192d29846cda548c0e29b265c032ea8db4a1bf043663</citedby><cites>FETCH-LOGICAL-c504t-e672a1595ea38778306eb192d29846cda548c0e29b265c032ea8db4a1bf043663</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1898963391/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1898963391?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25752,27923,27924,37011,37012,44589,53790,53792,74897</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26906452$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ahn, Matae</creatorcontrib><creatorcontrib>Cui, Jie</creatorcontrib><creatorcontrib>Irving, Aaron T.</creatorcontrib><creatorcontrib>Wang, Lin-Fa</creatorcontrib><title>Unique Loss of the PYHIN Gene Family in Bats Amongst Mammals: Implications for Inflammasome Sensing</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Recent genomic analysis of two bat species (
Pteropus alecto
and
Myotis davidii
) revealed the absence of the PYHIN gene family. This family is recognized as important immune sensors of intracellular self and foreign DNA and activators of the inflammasome and/or interferon pathways. Further assessment of a wider range of bat genomes was necessary to determine if this is a universal pattern for this large mammalian group. Here we expanded genomic analysis of this gene family to include ten bat species. We confirmed the complete loss of this gene family, with only a truncated
AIM2
remaining in one species (
Pteronotus parnellii
). Divergence of the PYHIN gene loci between the bat lineages infers different loss-of-function histories during bat evolution. While all other major groups of placental mammals have at least one gene member, only bats have lost the entire family. 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Cui, Jie ; Irving, Aaron T. ; Wang, Lin-Fa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c504t-e672a1595ea38778306eb192d29846cda548c0e29b265c032ea8db4a1bf043663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>631/181/2474</topic><topic>631/208/182</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>Bats</topic><topic>Chiroptera - genetics</topic><topic>Conserved Sequence</topic><topic>Deoxyribonucleic acid</topic><topic>Divergence</topic><topic>DNA</topic><topic>Evolution, Molecular</topic><topic>Genetic Loci</topic><topic>Genomes</topic><topic>Genomic analysis</topic><topic>Humanities and Social Sciences</topic><topic>Inflammasomes</topic><topic>Inflammasomes - physiology</topic><topic>Interferon</topic><topic>Mammals</topic><topic>multidisciplinary</topic><topic>Pyrin Domain</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Sensors</topic><topic>Sequence Analysis, DNA</topic><topic>Species</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ahn, Matae</creatorcontrib><creatorcontrib>Cui, Jie</creatorcontrib><creatorcontrib>Irving, Aaron T.</creatorcontrib><creatorcontrib>Wang, Lin-Fa</creatorcontrib><collection>SpringerOpen</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ahn, Matae</au><au>Cui, Jie</au><au>Irving, Aaron T.</au><au>Wang, Lin-Fa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Unique Loss of the PYHIN Gene Family in Bats Amongst Mammals: Implications for Inflammasome Sensing</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2016-02-24</date><risdate>2016</risdate><volume>6</volume><issue>1</issue><spage>21722</spage><epage>21722</epage><pages>21722-21722</pages><artnum>21722</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Recent genomic analysis of two bat species (
Pteropus alecto
and
Myotis davidii
) revealed the absence of the PYHIN gene family. This family is recognized as important immune sensors of intracellular self and foreign DNA and activators of the inflammasome and/or interferon pathways. Further assessment of a wider range of bat genomes was necessary to determine if this is a universal pattern for this large mammalian group. Here we expanded genomic analysis of this gene family to include ten bat species. We confirmed the complete loss of this gene family, with only a truncated
AIM2
remaining in one species (
Pteronotus parnellii
). Divergence of the PYHIN gene loci between the bat lineages infers different loss-of-function histories during bat evolution. While all other major groups of placental mammals have at least one gene member, only bats have lost the entire family. This removal of inflammasome DNA sensors may indicate an important adaptation that is flight-induced and related, at least in part, to pathogen-host co-existence.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>26906452</pmid><doi>10.1038/srep21722</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Scientific reports, 2016-02, Vol.6 (1), p.21722-21722, Article 21722 |
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| source | Open Access: PubMed Central; Publicly Available Content Database; Full-Text Journals in Chemistry (Open access); Springer Nature - nature.com Journals - Fully Open Access |
| subjects | 631/181/2474 631/208/182 Animals Base Sequence Bats Chiroptera - genetics Conserved Sequence Deoxyribonucleic acid Divergence DNA Evolution, Molecular Genetic Loci Genomes Genomic analysis Humanities and Social Sciences Inflammasomes Inflammasomes - physiology Interferon Mammals multidisciplinary Pyrin Domain Science Science (multidisciplinary) Sensors Sequence Analysis, DNA Species |
| title | Unique Loss of the PYHIN Gene Family in Bats Amongst Mammals: Implications for Inflammasome Sensing |
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