A spontaneously occurring malignant ovarian Sertoli cell tumor in a young Sprague Dawley rat

Primary ovarian tumors are generally uncommon in rats used in toxicologic studies. A malignant Sertoli cell tumor was present in the ovary of a 19-week-old female Sprague Dawley rat. Macroscopically, the mass was white and firm, 10 × 13 × 17 mm in size, and located in the right ovary. Histopathologi...

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Bibliographic Details
Published in:Journal of Toxicologic Pathology 2016, Vol.29(1), pp.53-59
Main Authors: Kinoshita, Yuichi, Yoshizawa, Katsuhiko, Emoto, Yuko, Yuki, Michiko, Yuri, Takashi, Shikata, Nobuaki, Elmore, Susan A., Tsubura, Airo
Format: Article
Language:English
Subjects:
Case Report
Cytoplasm
Estrogens
immunohistochemistry
Inhibin
Leukocytes (eosinophilic)
Literature reviews
Liver
malignant tumor
Mesentery
Metastases
Mimicry
Nuclei
Nuclei (cytology)
Ovarian cancer
ovary
Rats
Sertoli cell
Spleen
spontaneous
Stroma
Toxicity
Tubules
Tumor cells
Tumors
Vimentin
young rat
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Summary:Primary ovarian tumors are generally uncommon in rats used in toxicologic studies. A malignant Sertoli cell tumor was present in the ovary of a 19-week-old female Sprague Dawley rat. Macroscopically, the mass was white and firm, 10 × 13 × 17 mm in size, and located in the right ovary. Histopathologically, the mass was composed of nests of pleomorphic cells, which formed seminiferous-like tubules separated by a thin fibrovascular stroma. The tubules were lined by tumor cells, which had basally located nuclei and abundant eosinophilic and vacuolated cytoplasm. In some areas, the tumor cells were arranged in a retiform growth pattern, mimicking a rete testis/ovarii. Disseminated metastases to the surfaces of the mesentery, spleen and liver were also present. Immunohistochemically, many tumor cells were strongly positive for vimentin, estrogen receptor α and Ki 67. Some tumor cells were positive for pancytokeratin and inhibin α. These findings closely resemble those of an ovarian-derived human malignant Sertoli cell tumor. From our review of the literature, we believe this is the first report of a spontaneous malignant Sertoli cell tumor in the ovary of a young laboratory rat. This case might provide useful historical control information for rat toxicity studies.
ISSN:0914-9198
1881-915X
1347-7404
DOI:10.1293/tox.2015-0057