Genetic determinants of fibro-osseous lesions in aged inbred mice

Fibro-osseous lesions in mice are progressive aging changes in which the bone marrow is replaced to various degrees by fibrovascular stroma and bony trabeculae in a wide variety of bones. The frequency and severity varied greatly among 28 different inbred mouse stains, predominantly affecting female...

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Bibliographic Details
Published in:Experimental and molecular pathology 2016-02, Vol.100 (1), p.92-100
Main Authors: Berndt, Annerose, Ackert-Bicknell, Cheryl, Silva, Kathleen A., Kennedy, Victoria E., Sundberg, Beth A., Cates, Justin M., Schofield, Paul N., Sundberg, John P.
Format: Article
Language:English
Subjects:
Aging
Animals
Bone
Bone Diseases - pathology
Bone Marrow - pathology
Female
Fibrosis
Genome-wide association studies
Genome-Wide Association Study
KK/HlJ mice
Male
Mice
Mice, Inbred Strains
Rodent Diseases - genetics
Sex Factors
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Summary:Fibro-osseous lesions in mice are progressive aging changes in which the bone marrow is replaced to various degrees by fibrovascular stroma and bony trabeculae in a wide variety of bones. The frequency and severity varied greatly among 28 different inbred mouse stains, predominantly affecting females, ranging from 0% for 10 strains to 100% for KK/HlJ and NZW/LacJ female mice. Few lesions were observed in male mice and for 23 of the strains, no lesions were observed in males for any of the cohorts. There were no significant correlations between strain-specific severities of fibro-osseous lesions and ovarian (r=0.11; P=0.57) or endometrial (r=0.03; P=0.89) cyst formation frequency or abnormalities in parathyroid glands. Frequency of fibro-osseous lesions was most strongly associated (P
ISSN:0014-4800
1096-0945
DOI:10.1016/j.yexmp.2015.11.018