Glycosyltransferases and non-alcoholic fatty liver disease

Non-alcoholic fatty liver disease(NAFLD) is the most common form of chronic liver disease and its incidence is increasing worldwide. However, the underlying mechanisms leading to the development of NAFLD are still not fully understood. Glycosyltransferases(GTs) are a diverse class of enzymes involve...

Full description

Saved in:
Bibliographic Details
Published in:World journal of gastroenterology : WJG 2016-02, Vol.22 (8), p.2483-2493
Main Authors: Zhan, Yu-Tao, Su, Hai-Ying, An, Wei
Format: Article
Language:English
Subjects:
Adipose Tissue - enzymology
Adipose Tissue - pathology
Animals
disease
Pathogenesis
Glycosyltransferases
Glycosylation
fatty
Glycosylation
Glycosyltransferases - metabolism
Humans
liver
Liver - enzymology
Liver - pathology
Non-alcoholic
Non-alcoholic Fatty Liver Disease - enzymology
Non-alcoholic Fatty Liver Disease - pathology
Protein Processing, Post-Translational
Review
Signal Transduction
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Non-alcoholic fatty liver disease(NAFLD) is the most common form of chronic liver disease and its incidence is increasing worldwide. However, the underlying mechanisms leading to the development of NAFLD are still not fully understood. Glycosyltransferases(GTs) are a diverse class of enzymes involved in catalyzing the transfer of one or multiple sugar residues to a wide range of acceptor molecules. GTs mediate a wide range of functions from structure and storage to signaling, and play a key role in many fundamental biological processes. Therefore, it is anticipated that GTs have a role in the pathogenesis of NAFLD. In this article, we present an overview of the basic information on NAFLD, particularly GTs and glycosylation modification of certain molecules and their association with NAFLD pathogenesis. In addition, the effects and mechanisms of some GTs in the development of NAFLD are summarized.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v22.i8.2483