Subtype associations with HIV-associated neurocognitive disorder in China

• Published in: Journal of neurovirology 2016-04, Vol.22 (2), p.246-250
• Main Authors: Day, Tyler R. C., Smith, Davey M., Heaton, Robert K., Franklin, Donald, Tilghman, Myers W., Letendre, Scott, Jin, Hua, Wu, Zunyou, Shi, Chuan, Yu, Xin, Pérez-Santiago, Josué
• Format: Article
• Language: English
• Subjects: Adult; Anti-HIV Agents - therapeutic use; Antiretroviral Therapy, Highly Active; Biomedical and Life Sciences; Biomedicine; CD4 Lymphocyte Count; China; Cognitive Dysfunction - complications; Cognitive Dysfunction - drug therapy; Cognitive Dysfunction - physiopathology; Cognitive Dysfunction - virology; Cohort Studies; Executive Function; Female; Genotype; HIV Infections - complications; HIV Infections - drug therapy; HIV Infections - physiopathology; HIV Infections - virology; HIV-1 - classification; HIV-1 - drug effects; HIV-1 - genetics; Humans; Immunology; Infectious Diseases; Lentivirus; Male; Neurology; Neuropsychological Tests; Neurosciences; Psychomotor Performance; Retroviridae; Risk Factors; Short Communication; Viral Load - drug effects; Virology
• ISSN: 1355-0284; 1538-2443
• DOI: 10.1007/s13365-015-0377-4

Factors associated with HIV-associated neurocognitive disorders (HAND) include CD4 + nadir and count, HIV RNA level, and HIV-1 subtype. Here, we investigated demographical and clinical markers with respect to HAND in a homogenous Chinese population. Individuals with HAND (global deficit score ≥0.5) had lower nadir ( p <  0.01) and CD4 + counts ( p  = 0.03). HAND was also associated with AIDS ( p <  0.01), but subtype was not ( p  = 0.198). Furthermore, worse impairment correlated with higher viral diversity ( r  = 0.16, p <  0.01), lower nadir ( r  = −0.17, p <  0.01), and CD4 + counts ( r  = −0.11, p  = 0.01). These remained significant even when correcting for subtype. Our findings suggest that subtype does not have a major impact on HAND.