The ethnicity-specific association of biomarkers with the angiographic severity of coronary artery disease

• Published in: Netherlands heart journal 2016-03, Vol.24 (3), p.188-198
• Main Authors: Gijsberts, C. M., Seneviratna, A., Bank, I. E. M., den Ruijter, H. M., Asselbergs, F. W., Agostoni, P., Remijn, J. A., Pasterkamp, G., Kiat, H. C., Roest, M., Richards, A. M., Chan, M. Y., de Kleijn, D. P. V., Hoefer, I. E.
• Format: Article
• Language: English
• Subjects: Acute coronary syndromes; Antibodies; Beta blockers; Biomarkers; Body mass index; Cardiology; Cardiovascular disease; Coronary vessels; Cultural differences; Diabetes; Endocrine system; Ethnicity; Heart attacks; Hypertension; Medical Education; Medical imaging; Medicine; Medicine & Public Health; Minority & ethnic groups; Original - ICIN; Original Article - ICIN; Peptides; Transient ischemic attack; Variables; Vein & artery diseases; White people
• ISSN: 1568-5888; 1876-6250
• DOI: 10.1007/s12471-015-0798-y

Background Risk factor burden and clinical characteristics of patients with coronary artery disease (CAD) differ among ethnic groups. We related biomarkers to CAD severity in Caucasians, Chinese, Indians and Malays. Methods In the Dutch-Singaporean UNICORN coronary angiography cohort ( n  = 2033) we compared levels of five cardiovascular biomarkers: N-terminal pro-brain natriuretic peptide (NTproBNP), high-sensitivity C-reactive protein (hsCRP), cystatin C (CysC), myeloperoxidase (MPO) and high-sensitivity troponin I (hsTnI). We assessed ethnicity-specific associations of biomarkers with CAD severity, quantified by the SYNTAX score. Results Adjusted for baseline differences, NTproBNP levels were significantly higher in Malays than in Chinese and Caucasians (72.1 vs. 34.4 and 41.1 pmol/l, p