Some observations on complement-fixing antibodies to the EB virus

Complement-fixing antibodies against an antigen prepared from the EB3 line of cultured Burkitt tumour cells were studied in various groups of patients and control individuals. Higher antibody titres were observed in patients with Burkitt's tumour than in African patients with other diagnoses. S...

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Bibliographic Details
Published in:Journal of clinical pathology 1971-12, Vol.24 (9), p.801-804
Main Authors: Sutton, R. N. P., Marston, S. D., Emond, R. T. D.
Format: Article
Language:English
Subjects:
Antibodies - analysis
Antigens
Antigens, Viral
Burkitt Lymphoma - immunology
Cell Line
Complement Fixation Tests
Culture Techniques
Fluorescent Antibody Technique
Herpesviridae - immunology
Herpesvirus 4, Human - immunology
Humans
Infectious Mononucleosis - immunology
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Summary:Complement-fixing antibodies against an antigen prepared from the EB3 line of cultured Burkitt tumour cells were studied in various groups of patients and control individuals. Higher antibody titres were observed in patients with Burkitt's tumour than in African patients with other diagnoses. Significantly more medical students and nurses with a history of infectious mononucleosis possessed antibodies than those with no such history. Low levels of antibody were observed in patients during the acute phase of infectious mononucleosis and these levels were significantly lower than those in patients admitted to the same hospital with other diagnoses. During the early months following the acute phase of illness, EB complement-fixing antibodies remained stationary or apparently declined in titre but, in patients tested one or more years later, significantly higher antibody levels were observed.
ISSN:0021-9746
1472-4146
DOI:10.1136/jcp.24.9.801