Inflammatory arthritis in HIV positive patients: A practical guide

Musculoskeletal manifestations of the human immunodeficiency virus (HIV) have been described since the outset of the global HIV epidemic. Articular syndromes that have been described in association with HIV include HIV-associated arthropathy, seronegative spondyloarthropathies (SPA) (reactive arthri...

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Bibliographic Details
Published in:BMC infectious diseases 2016-03, Vol.16 (94), p.100-100, Article 100
Main Authors: Adizie, T, Moots, R J, Hodkinson, B, French, N, Adebajo, A O
Format: Article
Language:English
Subjects:
Adult
Antirheumatic agents
Antirheumatic Agents - therapeutic use
Arthritis
Arthritis - diagnosis
Arthritis - drug therapy
Arthritis - virology
Care and treatment
Complications and side effects
Health aspects
HIV infection
HIV Infections - complications
Humans
Immunosuppressive Agents - therapeutic use
Infectious diseases
Influence
Risk factors
Syndrome
Tumor necrosis factor
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Description
Summary:Musculoskeletal manifestations of the human immunodeficiency virus (HIV) have been described since the outset of the global HIV epidemic. Articular syndromes that have been described in association with HIV include HIV-associated arthropathy, seronegative spondyloarthropathies (SPA) (reactive arthritis, psoriatic arthritis (PsA) and undifferentiated SPA), rheumatoid arthritis (RA) and painful articular syndrome. We carried out a computer-assisted search of PubMed for the medical literature from January 1981 to January 2015 using the keywords HIV, acquired immune-deficiency syndrome, rheumatic manifestations, arthritis, spondyloarthropathy, anti-TNF and disease modifying antirheumatic drugs. Only English language literature was included and only studies involving adult human subjects were assessed. There are challenges in the management of inflammatory arthritis in patients who are HIV-positive, including difficulties in the assessment of disease activity and limited information on the safety of immunosuppressive drugs in these individuals. This review focuses on the clinical characteristics of the inflammatory articular syndromes that have been described in association with HIV infection and discusses the therapeutic options for these patients.
ISSN:1471-2334
1471-2334
DOI:10.1186/s12879-016-1389-2