Pulmonary fibrosis following therapy with Melphalan for multiple myeloma

A patient suffering from multiple myeloma developed pulmonary fibrosis, of a type known to be associated wtih busulphan, whilst being treated with Melphalan. The possible role of Melphalan as the causative agent is discussed. Reference is made to other possible aetiological agents and the reasons fo...

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Bibliographic Details
Published in:Journal of clinical pathology 1972-08, Vol.25 (8), p.668-673
Main Authors: Codling, B. W., Chakera, T. M. H.
Format: Article
Language:English
Subjects:
Autopsy
Bronchi - pathology
Humans
Hyperplasia
Lung - pathology
Male
Melphalan - adverse effects
Melphalan - therapeutic use
Middle Aged
Multiple Myeloma - drug therapy
Pulmonary Alveoli - pathology
Pulmonary Fibrosis - chemically induced
Pulmonary Fibrosis - etiology
Pulmonary Fibrosis - pathology
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Summary:A patient suffering from multiple myeloma developed pulmonary fibrosis, of a type known to be associated wtih busulphan, whilst being treated with Melphalan. The possible role of Melphalan as the causative agent is discussed. Reference is made to other possible aetiological agents and the reasons for their exclusion are discussed.
ISSN:0021-9746
1472-4146
DOI:10.1136/jcp.25.8.668