Resistance of Staphylococcus aureus to sulphamethoxazole and trimethoprim

Strains of Staphylococcus aureus isolated from the lesions of hospital patients were surveyed for resistance to sulphamethoxazole and to trimethoprim. Of 675 strains tested, 18·5% were resistant to sulphamethoxazole and 1·6% to trimethoprim. All the trimethoprim-resistant strains were resistant to s...

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Bibliographic Details
Published in:Journal of clinical pathology 1972-08, Vol.25 (8), p.708-712
Main Author: Nakhla, L. S.
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Bacitracin - pharmacology
Bacteriophage Typing
Drug Resistance, Microbial
Folic Acid Antagonists - pharmacology
Fusidic Acid - pharmacology
Humans
Lincomycin - pharmacology
Microbial Sensitivity Tests
Neomycin - pharmacology
Oleandomycin
Penicillin Resistance
Pyrimidines - pharmacology
Staphylococcus - drug effects
Streptomycin - pharmacology
Sulfamethoxazole - pharmacology
Sulfonamides - pharmacology
Tetracycline - pharmacology
Trimethoprim - pharmacology
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Summary:Strains of Staphylococcus aureus isolated from the lesions of hospital patients were surveyed for resistance to sulphamethoxazole and to trimethoprim. Of 675 strains tested, 18·5% were resistant to sulphamethoxazole and 1·6% to trimethoprim. All the trimethoprim-resistant strains were resistant to sulphamethoxazole and to a 1:20 mixture of the two drugs. Trimethoprim-resistant strains were on average more resistant to sulphamethoxazole than were trimethoprim-sensitive strains. They were all resistant to several other antimicrobial agents. Most of them had the phage-typing pattern 84/85, 84, or 85.
ISSN:0021-9746
1472-4146
DOI:10.1136/jcp.25.8.708