The isolation of enteroviruses from cases of acute conjunctivitis

In two epidemics of acute enterovirus conjunctivitis the diagnosis could only be established by the use of human embryonic organ cultures. In one instance cultures of ciliated respiratory epithelium proved sensitive to the virus but similar culture failed to support growth of the virus from the seco...

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Bibliographic Details
Published in:Journal of clinical pathology 1973-09, Vol.26 (9), p.706-711
Main Authors: Higgins, P. G., Scott, R. J. D.
Format: Article
Language:English
Subjects:
Animals
Conjunctivitis - diagnosis
Conjunctivitis - microbiology
Embryo, Mammalian
England
Enterovirus - isolation & purification
Epithelium - embryology
Epithelium - microbiology
Haplorhini
Humans
Indonesia
Intestines - embryology
Intestines - microbiology
Kidney - embryology
Kidney - microbiology
Nose - embryology
Nose - microbiology
Organ Culture Techniques
Singapore
Trachea - embryology
Trachea - microbiology
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Summary:In two epidemics of acute enterovirus conjunctivitis the diagnosis could only be established by the use of human embryonic organ cultures. In one instance cultures of ciliated respiratory epithelium proved sensitive to the virus but similar culture failed to support growth of the virus from the second outbreak which was isolated in organ cultures of conjunctiva. The virus associated with a third outbreak had previously been isolated from the original material by culture in human embryo kidney cells, but it required passage in organ culture for its detection after the specimens had been diluted.
ISSN:0021-9746
1472-4146
DOI:10.1136/jcp.26.9.706