Cellular Therapies in Systemic Sclerosis: Recent Progress

Systemic sclerosis (SSc) is a rare autoimmune connective tissue disease with a high mortality and morbidity. While progress has been made in terms of identifying high-risk patients and implementing new treatment strategies, therapeutic options remain limited. In the past few decades, various cellula...

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Bibliographic Details
Published in:Current rheumatology reports 2016-02, Vol.18 (2), p.12-12, Article 12
Main Authors: van Rhijn-Brouwer, Femke C. C., Gremmels, Hendrik, Fledderus, Joost O., Radstake, Timothy R. D., Verhaar, Marianne C., van Laar, Jacob M.
Format: Article
Language:English
Subjects:
Clinical Trials as Topic - methods
Dendritic Cells - transplantation
Hematopoietic Stem Cell Transplantation - methods
Hematopoietic Stem Cell Transplantation - trends
Humans
Medicine
Medicine & Public Health
Mesenchymal Stem Cell Transplantation - methods
Mesenchymal Stem Cell Transplantation - trends
Rheumatology
Scleroderma (J Varga
Scleroderma (J Varga, Section Editor)
Scleroderma, Systemic - therapy
Section Editor
T-Lymphocytes, Regulatory - transplantation
Topical Collection on Scleroderma
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Summary:Systemic sclerosis (SSc) is a rare autoimmune connective tissue disease with a high mortality and morbidity. While progress has been made in terms of identifying high-risk patients and implementing new treatment strategies, therapeutic options remain limited. In the past few decades, various cellular therapies have emerged, which have been studied in SSc and other conditions. Here, we provide a comprehensive review of currently available cellular therapies and critically assess their merit as disease-modifying treatment for SSc. Currently, hematopoietic stem cell transplantation is the only cellular therapy that has demonstrated clinical effects on the immune system, neoangiogenesis, and fibrosis. Robust mechanistic studies as well as clinical trials are essential to move the field forward.
ISSN:1523-3774
1534-6307
DOI:10.1007/s11926-015-0555-7