The Efficacy and Safety of Fractional CO2 Laser Combined with Topical Type A Botulinum Toxin for Facial Rejuvenation: A Randomized Controlled Split-Face Study

Objective. We evaluated synergistic efficacy and safety of combined topical application of Botulinum Toxin Type A (BTX-A) with fractional CO2 laser for facial rejuvenation. Methods. Twenty female subjects were included for this split-face comparative study. One side of each subject’s cheek was treat...

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Bibliographic Details
Published in:BioMed research international 2016-01, Vol.2016 (2016), p.1-7
Main Authors: Zhou, Bing-rong, Zhang, Jia-an, Liu, Juan, Chen, Xiao-e, Li, Min, Ji, Xi, Zhu, Jie, Luo, Dan
Format: Article
Language:English
Subjects:
Administration, Topical
Adult
Botulinum Toxins, Type A - administration & dosage
Carbon dioxide
Cell growth
Clinical Study
Collagen
Cosmetic Techniques
Dermatology
Elasticity - drug effects
Erythema - etiology
Erythema - metabolism
Face
Female
Fibroblasts
Humans
Low-Level Light Therapy - methods
Maternal & child health
Melanins - metabolism
Middle Aged
Pain
Pilot Projects
Senescence
Skin - metabolism
Stem cells
Studies
Water Loss, Insensible - drug effects
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Summary:Objective. We evaluated synergistic efficacy and safety of combined topical application of Botulinum Toxin Type A (BTX-A) with fractional CO2 laser for facial rejuvenation. Methods. Twenty female subjects were included for this split-face comparative study. One side of each subject’s cheek was treated with fractional CO2 plus saline solution, and the other side was treated with fractional CO2 laser plus topical application of BTX-A. Patients received one session of treatment and evaluations were done at baseline, one, four, and twelve weeks after treatment. The outcome assessments included subjective satisfaction scale; blinded clinical assessment; and the biophysical parameters of roughness, elasticity, skin hydration, transepidermal water loss (TEWL), and the erythema and melanin index. Results. BTX-A combined with fractional CO2 laser sides showed higher physician’s global assessment score, subject satisfaction score, roughness, skin hydration, and skin elasticity compared to that of fractional CO2 plus saline solution side at 12 weeks after treatment. TEWL and erythema and melanin index showed no significant differences between two sides at baseline, one, four, and twelve weeks after treatment. Conclusion. Topical application of BTX-A could enhance the rejuvenation effect of fractional CO2 laser.
ISSN:2314-6133
2314-6141
DOI:10.1155/2016/3853754