Mitochondrial fusion and fission proteins as novel therapeutic targets for treating cardiovascular disease

The past decade has witnessed a number of exciting developments in the field of mitochondrial dynamics – a phenomenon in which changes in mitochondrial shape and movement impact on cellular physiology and pathology. By undergoing fusion and fission, mitochondria are able to change their morphology b...

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Bibliographic Details
Published in:European journal of pharmacology 2015-09, Vol.763 (Pt A), p.104-114
Main Authors: Ong, Sang-Bing, Kalkhoran, Siavash Beikoghli, Cabrera-Fuentes, Hector A., Hausenloy, Derek J.
Format: Article
Language:English
Subjects:
Animals
Cardiovascular Diseases - drug therapy
Cardiovascular Diseases - metabolism
Cardiovascular Diseases - pathology
Drp1
Humans
MFN1
MFN2
Mitochondrial Dynamics - drug effects
Mitochondrial fission
Mitochondrial fusion
Mitochondrial Proteins - metabolism
Molecular Targeted Therapy - methods
OPA1
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Summary:The past decade has witnessed a number of exciting developments in the field of mitochondrial dynamics – a phenomenon in which changes in mitochondrial shape and movement impact on cellular physiology and pathology. By undergoing fusion and fission, mitochondria are able to change their morphology between elongated interconnected networks and discrete fragmented structures, respectively. The cardiac mitochondria, in particular, have garnered much interest due to their unique spatial arrangement in the adult cardiomyocyte, and the multiple roles they play in cell death and survival. In this article, we review the role of the mitochondrial fusion and fission proteins as novel therapeutic targets for treating cardiovascular disease.
ISSN:0014-2999
1879-0712
DOI:10.1016/j.ejphar.2015.04.056