Treating Cocaine Addiction with Viruses

Cocaine addiction continues to be a major health and social problem in the United States and other countries. Currently used pharmacological agents for treating cocaine abuse have proved inadequate, leaving few treatment options. An alternative is to use protein-based therapeutics that can eliminate...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2004-07, Vol.101 (28), p.10416-10421
Main Authors: M. Rocio A. Carrera, Kaufmann, Gunnar F., Mee, Jenny M., Meijler, Michael M., Koob, George F., Janda, Kim D., Brenner, Sydney
Format: Article
Language:English
Subjects:
Administration, Intranasal
Animals
Antibodies
Bacteriophages
Biological Sciences
Brain - virology
Central nervous system
Cocaine
Cocaine - metabolism
Cocaine addiction
Cocaine-Related Disorders - therapy
Dopamine Uptake Inhibitors - metabolism
Dosage
Drug addiction
Inovirus - metabolism
Locomotion
Male
Medical treatment
Photoelectric cells
Psychomotor Agitation
Rats
Rats, Wistar
Rodentia
Stereotypies
Substance abuse treatment
Viruses
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Summary:Cocaine addiction continues to be a major health and social problem in the United States and other countries. Currently used pharmacological agents for treating cocaine abuse have proved inadequate, leaving few treatment options. An alternative is to use protein-based therapeutics that can eliminate the load of cocaine, thereby attenuating its effects. This approach is especially attractive because the therapeutic agents exert no pharmacodynamic action of their own and therefore have little potential for side effects. The effectiveness of these agents, however, is limited by their inability to act directly within the CNS. Bacteriophage have the capacity to penetrate the CNS when administered intranasally. Here, a method is presented for engineering filamentous bacteriophage to display cocaine-binding proteins on its surface that sequester cocaine in the brain. These antibody-displaying constructs were examined by using a locomotor activity rodent model to assess the ability of the phage-displayed proteins to block the psychoactive effects of cocaine. Results presented demonstrate a strategy in the continuing efforts to find effective treatments for cocaine addiction and suggest the application of this protein-based treatment for other drug abuse syndromes.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.0403795101