Alcohol and tobacco consumption alter hypothalamic pituitary adrenal axis DNA methylation

Highlights • Objective DNA methylation biomarkers can quantify smoking and alcohol consumption. • Substance use affects HPA axis DNA methylation. • Influence of substance use is more prominent at FKBP5 than NR3C1.

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Bibliographic Details
Published in:Psychoneuroendocrinology 2016-04, Vol.66, p.176-184
Main Authors: Dogan, Meeshanthini V, Lei, Man-Kit, Beach, Steven R.H, Brody, Gene H, Philibert, Robert A
Format: Article
Language:English
Subjects:
Adult
Aged
Alcohol Drinking - genetics
Cohort Studies
DNA methylation
DNA Methylation - drug effects
Drinking
Endocrinology & Metabolism
Epigenetics
Ethanol - pharmacology
Female
Genome-Wide Association Study
Humans
Hypothalamic pituitary adrenal axis
Hypothalamo-Hypophyseal System - drug effects
Hypothalamo-Hypophyseal System - metabolism
Male
Middle Aged
Pituitary-Adrenal System - drug effects
Pituitary-Adrenal System - metabolism
Psychiatric disorders
Psychiatry
Receptors, Glucocorticoid - genetics
Smoking
Tacrolimus Binding Proteins - genetics
Tobacco Use - genetics
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Description
Summary:Highlights • Objective DNA methylation biomarkers can quantify smoking and alcohol consumption. • Substance use affects HPA axis DNA methylation. • Influence of substance use is more prominent at FKBP5 than NR3C1.
ISSN:0306-4530
1873-3360
DOI:10.1016/j.psyneuen.2016.01.018