Tight junctions in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer

Inflammatory bowel diseases are characterised by inflammation that compromises the integrity of the epithelial barrier. The intestinal epithelium is not only a static barrier but has evolved complex mechanisms to control and regulate bacterial interactions with the mucosal surface. Apical tight junc...

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Bibliographic Details
Published in:World journal of gastroenterology : WJG 2016-03, Vol.22 (11), p.3117-3126
Main Authors: Landy, Jonathan, Ronde, Emma, English, Nick, Clark, Sue K, Hart, Ailsa L, Knight, Stella C, Ciclitira, Paul J, Al-Hassi, Hafid Omar
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents - pharmacology
Claudin
Tight
Claudins - metabolism
Colitis, Ulcerative - complications
Colitis, Ulcerative - drug therapy
Colitis, Ulcerative - metabolism
Colitis, Ulcerative - pathology
colitis
Pouchitis
Crohn’s
Colon - drug effects
Colon - metabolism
Colon - pathology
Colorectal Neoplasms - etiology
Colorectal Neoplasms - metabolism
Colorectal Neoplasms - pathology
Crohn Disease - complications
Crohn Disease - drug therapy
Crohn Disease - metabolism
Crohn Disease - pathology
disease
Humans
Inflammation Mediators - metabolism
Intestinal Mucosa - drug effects
Intestinal Mucosa - metabolism
Intestinal Mucosa - pathology
junction
Ulcerative
Permeability
Pouchitis - complications
Pouchitis - drug therapy
Pouchitis - metabolism
Pouchitis - pathology
Review
Tight Junctions - drug effects
Tight Junctions - metabolism
Tight Junctions - pathology
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Description
Summary:Inflammatory bowel diseases are characterised by inflammation that compromises the integrity of the epithelial barrier. The intestinal epithelium is not only a static barrier but has evolved complex mechanisms to control and regulate bacterial interactions with the mucosal surface. Apical tight junction proteins are critical in the maintenance of epithelial barrier function and control of paracellular permeability. The characterisation of alterations in tight junction proteins as key players in epithelial barrier function in inflammatory bowel diseases is rapidly enhancing our understanding of critical mechanisms in disease pathogenesis as well as novel therapeutic opportunities. Here we give an overview of recent literature focusing on the role of tight junction proteins, in particular claudins, in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v22.i11.3117