Diurnal intraocular pressure fluctuation and its risk factors in angle-closure and open-angle glaucoma

Purpose To evaluate intraocular pressure (IOP) fluctuation during office hours and its predictive factors in untreated primary angle-closure suspects (PACS); post-iridotomy primary angle closure (PAC) and primary angle-closure glaucoma (PACG) eyes with or without IOP-lowering medication(s) as approp...

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Bibliographic Details
Published in:Eye (London) 2016-03, Vol.30 (3), p.362-368
Main Authors: Srinivasan, S, Choudhari, N S, Baskaran, M, George, R J, Shantha, B, Vijaya, L
Format: Article
Language:English
Subjects:
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Aged
Biometry
Circadian Rhythm - physiology
Clinical Study
Corneal Pachymetry
Cross-Sectional Studies
Female
Glaucoma
Glaucoma, Angle-Closure - physiopathology
Glaucoma, Angle-Closure - surgery
Glaucoma, Open-Angle - physiopathology
Glaucoma, Open-Angle - surgery
Gonioscopy
Humans
Intraocular Pressure - physiology
Iridectomy
Iris - surgery
Laboratory Medicine
Laser Coagulation
Male
Medicine
Medicine & Public Health
Middle Aged
Ophthalmology
Pharmaceutical Sciences/Technology
Risk Factors
Surgery
Surgical Oncology
Tonometry, Ocular
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Summary:Purpose To evaluate intraocular pressure (IOP) fluctuation during office hours and its predictive factors in untreated primary angle-closure suspects (PACS); post-iridotomy primary angle closure (PAC) and primary angle-closure glaucoma (PACG) eyes with or without IOP-lowering medication(s) as appropriate and medically treated primary open-angle glaucoma (POAG) eyes. Methods One-hundred seventeen eyes (29 PACS, 30 PAC, 28 PACG, and 30 POAG) of 117 patients were included in this cross-sectional study. The subjects underwent hourly IOP measurements with Goldmann tonometer from 0800 to 1700 hours. Subjects with PAC and PACG had laser peripheral iridotomy at least 2 weeks prior to the inclusion. SD of office-hour IOP readings was the main outcome measure. Results IOP fluctuation differed between the groups ( P =0.01; Kruskal–Wallis Test). Post hoc Mann–Whitney U -tests showed significantly less IOP fluctuation in PACS compared with PACG ( P
ISSN:0950-222X
1476-5454
DOI:10.1038/eye.2015.231