Multifaceted functions and roles of HBZ in HTLV-1 pathogenesis

Human T cell leukemia virus type 1 (HTLV-1) is an oncogenic retrovirus responsible for the development of adult T-cell leukemia (ATL). Although HTLV-1 harbors an oncogene, tax, that transforms T cells in vitro and induces leukemia in transgenic mice, tax expression is frequently disrupted in ATL, ma...

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Bibliographic Details
Published in:Retrovirology 2016-03, Vol.13 (16), p.16-16, Article 16
Main Authors: Ma, Guangyong, Yasunaga, Jun-Ichirou, Matsuoka, Masao
Format: Article
Language:English
Subjects:
Animals
Basic-Leucine Zipper Transcription Factors - metabolism
Cancer
Care and treatment
Complications and side effects
DNA methylation
Genes
Genetic engineering
Host-Pathogen Interactions
HTLV-I Infections - virology
Human T-lymphotropic virus 1 - pathogenicity
Humans
Influence
Leukemia
Lymphocytes
Lymphoma, T-Cell - virology
Mice, Transgenic
Mutation
Pathogenesis
Proteins
Retroviridae Proteins - metabolism
Review
T cells
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Summary:Human T cell leukemia virus type 1 (HTLV-1) is an oncogenic retrovirus responsible for the development of adult T-cell leukemia (ATL). Although HTLV-1 harbors an oncogene, tax, that transforms T cells in vitro and induces leukemia in transgenic mice, tax expression is frequently disrupted in ATL, making the oncogenesis of ATL a bit mysterious. The HTLV-1 bZIP factor (HBZ) gene was discovered in 2002 and has been found to promote T-cell proliferation and cause lymphoma in transgenic mice. Thus HBZ has become a novel hotspot of HTLV-1 research. This review summarizes the current findings on HBZ with a special focus on its potential links to the oncogenesis of ATL. We propose viewing HBZ as a critical contributing factor in ATL development.
ISSN:1742-4690
1742-4690
DOI:10.1186/s12977-016-0249-x