Evaluation of C‐terminal Agrin Fragment as a marker of muscle wasting in patients after acute stroke during early rehabilitation

Background C‐terminal Agrin Fragment (CAF) has been proposed as a novel biomarker for sarcopenia originating from the degeneration of the neuromuscular junctions. In patients with stroke muscle wasting is a common observation that predicts functional outcome. We aimed to evaluate agrin sub‐fragment...

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Published in:Journal of cachexia, sarcopenia and muscle sarcopenia and muscle, 2016-03, Vol.7 (1), p.60-67
Main Authors: Scherbakov, Nadja, Knops, Michael, Ebner, Nicole, Valentova, Miroslava, Sandek, Anja, Grittner, Ulrike, Dahinden, Pius, Hettwer, Stefan, Schefold, Jörg C, Haehling, Stephan, Anker, Stefan D., Joebges, Michael, Doehner, Wolfram
Format: Article
Language:English
Subjects:
Authorship
Body composition
Body mass index
C‐terminal Agrin Fragment
Dielectric properties
Edema
Enzymes
Muscle wasting
Musculoskeletal system
Neuromuscular diseases
Older people
Original
Physical performance
Post‐stroke rehabilitation
Rehabilitation
Sarcopenia
Skeletal muscle mass
Stroke
Studies
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Summary:Background C‐terminal Agrin Fragment (CAF) has been proposed as a novel biomarker for sarcopenia originating from the degeneration of the neuromuscular junctions. In patients with stroke muscle wasting is a common observation that predicts functional outcome. We aimed to evaluate agrin sub‐fragment CAF22 as a marker of decreased muscle mass and physical performance in the early phase after acute stroke. Methods Patients with acute ischaemic or haemorrhagic stroke (n = 123, mean age 70 ± 11 y, body mass index BMI 27.0 ± 4.9 kg/m2) admitted to inpatient rehabilitation were studied in comparison to 26 healthy controls of similar age and BMI. Functional assessments were performed at begin (23 ± 17 days post stroke) and at the end of the structured rehabilitation programme (49 ± 18 days post stroke) that included physical assessment, maximum hand grip strength, Rivermead motor assessment, and Barthel index. Body composition was assessed by bioelectrical impedance analysis (BIA). Serum levels of CAF22 were measured by ELISA. Results CAF22 levels were elevated in stroke patients at admission (134.3 ± 52.3 pM) and showed incomplete recovery until discharge (118.2 ± 42.7 pM) compared to healthy controls (95.7 ± 31.8 pM, p 
ISSN:2190-5991
2190-6009
DOI:10.1002/jcsm.12068