Tailoring the spectral response of liquid waveguide diagnostic platforms

Liquid filled waveguides that form the basis for on‐chip biophotonics diagnostic platforms have primarily found application in fluorescence and Raman spectroscopy experiments that require sensitive discrimination between weak analyte signals and a variety of background signals. Primary sources of ba...

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Bibliographic Details
Published in:Journal of biophotonics 2012-08, Vol.5 (8-9), p.703-711
Main Authors: Zhao, Yue, Phillips, Brian, Ozcelik, Damla, Parks, Joshua, Measor, Philip, Gulbransen, David, Schmidt, Holger, Hawkins, Aaron R.
Format: Article
Language:English
Subjects:
filter
hollow waveguides
integrated optics
Luminescence
Microfluidic Analytical Techniques - instrumentation
Optical Devices
optofluidics
signal-to-noise ratio
Spectrum Analysis
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Summary:Liquid filled waveguides that form the basis for on‐chip biophotonics diagnostic platforms have primarily found application in fluorescence and Raman spectroscopy experiments that require sensitive discrimination between weak analyte signals and a variety of background signals. Primary sources of background signal can include light from excitation sources (strong, narrow frequency band) and photoluminescence generated in waveguide cladding layers (weak, wide frequency band). Here we review both solid and liquid core filtering structures which are based on anti‐resonant reflection that can be integrated with waveguides for attenuating undesirable optical bands. Important criteria to consider for an optimized biosensor include cladding layer materials that minimize broad‐spectrum photoluminescence and optimize layer thicknesses for creating a desired spectral response in both solid and liquid guiding layers, and a microfabrication process capable of producing regions with variable spectral response. New results describing how spurious fluorescence can be minimized by optimized thermal growth conditions and how liquid‐core filter discrimination can be tuned with liquid core waveguide length are presented. (© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
ISSN:1864-063X
1864-0648
DOI:10.1002/jbio.201200049