Endothelial nitric oxide synthase: a potential therapeutic target for cerebrovascular diseases

Endothelial nitric oxide (NO) is a significant signaling molecule that regulates cerebral blood flow (CBF), playing a pivotal role in the prevention and treatment of cerebrovascular diseases. However, achieving the expected therapeutic efficacy is difficult using direct administration of NO donors....

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Bibliographic Details
Published in:Molecular brain 2016-03, Vol.9 (1), p.30-30, Article 30
Main Authors: Zhu, Jinqiang, Song, Wanshan, Li, Lin, Fan, Xiang
Format: Article
Language:English
Subjects:
Animals
Cerebrovascular Circulation
Cerebrovascular Disorders - enzymology
Cerebrovascular Disorders - physiopathology
Cerebrovascular Disorders - therapy
Humans
Kinases
Models, Biological
Molecular Targeted Therapy
Nitric oxide
Nitric Oxide Synthase Type III - metabolism
Review
Traumatic brain injury
Veins & arteries
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Summary:Endothelial nitric oxide (NO) is a significant signaling molecule that regulates cerebral blood flow (CBF), playing a pivotal role in the prevention and treatment of cerebrovascular diseases. However, achieving the expected therapeutic efficacy is difficult using direct administration of NO donors. Therefore, endothelial nitric oxide synthase (eNOS) becomes a potential therapeutic target for cerebrovascular diseases. This review summarizes the current evidence supporting the importance of CBF to cerebrovascular function, and the roles of NO and eNOS in CBF regulation.
ISSN:1756-6606
1756-6606
DOI:10.1186/s13041-016-0211-9