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Epidemiology of infant meningococcal disease in the United States, 2006-2012
The incidence of meningococcal disease is currently at historic lows in the United States; however, incidence remains highest among infants aged
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| Published in: | Pediatrics (Evanston) 2015-02, Vol.135 (2), p.e305-e311 |
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| container_end_page | e311 |
| container_issue | 2 |
| container_start_page | e305 |
| container_title | Pediatrics (Evanston) |
| container_volume | 135 |
| creator | MacNeil, Jessica R Bennett, Nancy Farley, Monica M Harrison, Lee H Lynfield, Ruth Nichols, Megin Petit, Sue Reingold, Arthur Schaffner, William Thomas, Ann Pondo, Tracy Mayer, Leonard W Clark, Thomas A Cohn, Amanda C |
| description | The incidence of meningococcal disease is currently at historic lows in the United States; however, incidence remains highest among infants aged |
| doi_str_mv | 10.1542/peds.2014-2035 |
| format | article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4803024</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A402600804</galeid><sourcerecordid>A402600804</sourcerecordid><originalsourceid>FETCH-LOGICAL-c489t-2584b9f744e0e45f59b91f819775e77afee75e6f4797beae3da235c4f88a8a183</originalsourceid><addsrcrecordid>eNqNks1v1DAQxS1ERZfClSOKxIUDWcZfsXNBqlYFKq3UQ-nZ8jrj1FViL7G3ov89ibZUwKknjzS_eR4_P0LeUVhTKdjnPXZ5zYCKmgGXL8iKQqtrwZR8SVYAnNYCQJ6S1znfAYCQir0ip0xKzVtGV2R7sQ8djiENqX-okq9C9DaWasQYYp9ccs4OVRcy2oxzsyq3WN3EULCrrostmD9VDKCZr6fsDTnxdsj49vE8IzdfL35svtfbq2-Xm_Nt7YRuS82kFrvWKyEQUEgv211LvaatUhKVsh5xLhovVKt2aJF3lnHphNfaaks1PyNfjrr7w27EzmEskx3MfgqjnR5MssH824nh1vTp3ggNHJiYBT4-Ckzp5wFzMWPIDofBRkyHbGjTaCaBc_kMVDIhG6qaGf3wH3qXDlOcnVgoyWUjlZqp-kj1dkATokux4K_i0jBgj2Y2anNlzgWwBkDDsuv6yLsp5Tyhf3onBbNkwCwZMEsGzJKBeeD93-484X8-nf8G_E2qNw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1655356577</pqid></control><display><type>article</type><title>Epidemiology of infant meningococcal disease in the United States, 2006-2012</title><source>EZB-FREE-00999 freely available EZB journals</source><creator>MacNeil, Jessica R ; Bennett, Nancy ; Farley, Monica M ; Harrison, Lee H ; Lynfield, Ruth ; Nichols, Megin ; Petit, Sue ; Reingold, Arthur ; Schaffner, William ; Thomas, Ann ; Pondo, Tracy ; Mayer, Leonard W ; Clark, Thomas A ; Cohn, Amanda C</creator><creatorcontrib>MacNeil, Jessica R ; Bennett, Nancy ; Farley, Monica M ; Harrison, Lee H ; Lynfield, Ruth ; Nichols, Megin ; Petit, Sue ; Reingold, Arthur ; Schaffner, William ; Thomas, Ann ; Pondo, Tracy ; Mayer, Leonard W ; Clark, Thomas A ; Cohn, Amanda C</creatorcontrib><description>The incidence of meningococcal disease is currently at historic lows in the United States; however, incidence remains highest among infants aged <1 year. With routine use of Haemophilus influenzae type b and pneumococcal vaccines in infants and children in the United States, Neisseria meningitidis remains an important cause of bacterial meningitis in young children.
Data were collected from active, population- and laboratory-based surveillance for N meningitidis conducted through Active Bacterial Core surveillance during 2006 through 2012. Expanded data collection forms were completed for infant cases identified in the surveillance area during 2006 through 2010.
An estimated 113 cases of culture-confirmed meningococcal disease occurred annually among infants aged <1 year in the United States from 2006 through 2012, for an overall incidence of 2.74 per 100,000 infants. Among these cases, an estimated 6 deaths occurred. Serogroup B was responsible for 64%, serogroup C for 12%, and serogroup Y for 16% of infant cases. Based on the expanded data collection forms, a high proportion of infant cases (36/58, 62%) had a smoker in the household and the socioeconomic status of the census tracts where infant meningococcal cases resided was lower compared with the other Active Bacterial Core surveillance areas and the United States as a whole.
The burden of meningococcal disease remains highest in young infants and serogroup B predominates. Vaccines that provide long-term protection early in life have the potential to reduce the burden of meningococcal disease, especially if they provide protection against serogroup B meningococcal disease.</description><identifier>ISSN: 0031-4005</identifier><identifier>EISSN: 1098-4275</identifier><identifier>DOI: 10.1542/peds.2014-2035</identifier><identifier>PMID: 25583921</identifier><identifier>CODEN: PEDIAU</identifier><language>eng</language><publisher>United States: American Academy of Pediatrics</publisher><subject>Analysis ; Babies ; Care and treatment ; Data collection ; Dosage and administration ; Epidemiology ; Female ; Haemophilus influenzae ; Health aspects ; Humans ; Incidence ; Infant ; Infants ; Male ; Meningitis ; Meningitis, Meningococcal - epidemiology ; Meningitis, Meningococcal - microbiology ; Meningitis, Meningococcal - prevention & control ; Meningococcal infections ; Meningococcal Vaccines - administration & dosage ; Neisseria meningitidis ; Neisseria meningitidis, Serogroup B - pathogenicity ; Neisseria meningitidis, Serogroup Y - pathogenicity ; Pediatrics ; Pneumococcal vaccine ; Pneumococcal vaccines ; Population Surveillance ; Risk factors ; Streptococcus pneumoniae ; Survival Rate ; United States ; Vaccines ; Virulence</subject><ispartof>Pediatrics (Evanston), 2015-02, Vol.135 (2), p.e305-e311</ispartof><rights>Copyright © 2015 by the American Academy of Pediatrics.</rights><rights>Copyright American Academy of Pediatrics Feb 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c489t-2584b9f744e0e45f59b91f819775e77afee75e6f4797beae3da235c4f88a8a183</citedby><cites>FETCH-LOGICAL-c489t-2584b9f744e0e45f59b91f819775e77afee75e6f4797beae3da235c4f88a8a183</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25583921$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MacNeil, Jessica R</creatorcontrib><creatorcontrib>Bennett, Nancy</creatorcontrib><creatorcontrib>Farley, Monica M</creatorcontrib><creatorcontrib>Harrison, Lee H</creatorcontrib><creatorcontrib>Lynfield, Ruth</creatorcontrib><creatorcontrib>Nichols, Megin</creatorcontrib><creatorcontrib>Petit, Sue</creatorcontrib><creatorcontrib>Reingold, Arthur</creatorcontrib><creatorcontrib>Schaffner, William</creatorcontrib><creatorcontrib>Thomas, Ann</creatorcontrib><creatorcontrib>Pondo, Tracy</creatorcontrib><creatorcontrib>Mayer, Leonard W</creatorcontrib><creatorcontrib>Clark, Thomas A</creatorcontrib><creatorcontrib>Cohn, Amanda C</creatorcontrib><title>Epidemiology of infant meningococcal disease in the United States, 2006-2012</title><title>Pediatrics (Evanston)</title><addtitle>Pediatrics</addtitle><description>The incidence of meningococcal disease is currently at historic lows in the United States; however, incidence remains highest among infants aged <1 year. With routine use of Haemophilus influenzae type b and pneumococcal vaccines in infants and children in the United States, Neisseria meningitidis remains an important cause of bacterial meningitis in young children.
Data were collected from active, population- and laboratory-based surveillance for N meningitidis conducted through Active Bacterial Core surveillance during 2006 through 2012. Expanded data collection forms were completed for infant cases identified in the surveillance area during 2006 through 2010.
An estimated 113 cases of culture-confirmed meningococcal disease occurred annually among infants aged <1 year in the United States from 2006 through 2012, for an overall incidence of 2.74 per 100,000 infants. Among these cases, an estimated 6 deaths occurred. Serogroup B was responsible for 64%, serogroup C for 12%, and serogroup Y for 16% of infant cases. Based on the expanded data collection forms, a high proportion of infant cases (36/58, 62%) had a smoker in the household and the socioeconomic status of the census tracts where infant meningococcal cases resided was lower compared with the other Active Bacterial Core surveillance areas and the United States as a whole.
The burden of meningococcal disease remains highest in young infants and serogroup B predominates. Vaccines that provide long-term protection early in life have the potential to reduce the burden of meningococcal disease, especially if they provide protection against serogroup B meningococcal disease.</description><subject>Analysis</subject><subject>Babies</subject><subject>Care and treatment</subject><subject>Data collection</subject><subject>Dosage and administration</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Haemophilus influenzae</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infant</subject><subject>Infants</subject><subject>Male</subject><subject>Meningitis</subject><subject>Meningitis, Meningococcal - epidemiology</subject><subject>Meningitis, Meningococcal - microbiology</subject><subject>Meningitis, Meningococcal - prevention & control</subject><subject>Meningococcal infections</subject><subject>Meningococcal Vaccines - administration & dosage</subject><subject>Neisseria meningitidis</subject><subject>Neisseria meningitidis, Serogroup B - pathogenicity</subject><subject>Neisseria meningitidis, Serogroup Y - pathogenicity</subject><subject>Pediatrics</subject><subject>Pneumococcal vaccine</subject><subject>Pneumococcal vaccines</subject><subject>Population Surveillance</subject><subject>Risk factors</subject><subject>Streptococcus pneumoniae</subject><subject>Survival Rate</subject><subject>United States</subject><subject>Vaccines</subject><subject>Virulence</subject><issn>0031-4005</issn><issn>1098-4275</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNqNks1v1DAQxS1ERZfClSOKxIUDWcZfsXNBqlYFKq3UQ-nZ8jrj1FViL7G3ov89ibZUwKknjzS_eR4_P0LeUVhTKdjnPXZ5zYCKmgGXL8iKQqtrwZR8SVYAnNYCQJ6S1znfAYCQir0ip0xKzVtGV2R7sQ8djiENqX-okq9C9DaWasQYYp9ccs4OVRcy2oxzsyq3WN3EULCrrostmD9VDKCZr6fsDTnxdsj49vE8IzdfL35svtfbq2-Xm_Nt7YRuS82kFrvWKyEQUEgv211LvaatUhKVsh5xLhovVKt2aJF3lnHphNfaaks1PyNfjrr7w27EzmEskx3MfgqjnR5MssH824nh1vTp3ggNHJiYBT4-Ckzp5wFzMWPIDofBRkyHbGjTaCaBc_kMVDIhG6qaGf3wH3qXDlOcnVgoyWUjlZqp-kj1dkATokux4K_i0jBgj2Y2anNlzgWwBkDDsuv6yLsp5Tyhf3onBbNkwCwZMEsGzJKBeeD93-484X8-nf8G_E2qNw</recordid><startdate>20150201</startdate><enddate>20150201</enddate><creator>MacNeil, Jessica R</creator><creator>Bennett, Nancy</creator><creator>Farley, Monica M</creator><creator>Harrison, Lee H</creator><creator>Lynfield, Ruth</creator><creator>Nichols, Megin</creator><creator>Petit, Sue</creator><creator>Reingold, Arthur</creator><creator>Schaffner, William</creator><creator>Thomas, Ann</creator><creator>Pondo, Tracy</creator><creator>Mayer, Leonard W</creator><creator>Clark, Thomas A</creator><creator>Cohn, Amanda C</creator><general>American Academy of Pediatrics</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>U9A</scope><scope>7X8</scope><scope>7QL</scope><scope>C1K</scope><scope>5PM</scope></search><sort><creationdate>20150201</creationdate><title>Epidemiology of infant meningococcal disease in the United States, 2006-2012</title><author>MacNeil, Jessica R ; Bennett, Nancy ; Farley, Monica M ; Harrison, Lee H ; Lynfield, Ruth ; Nichols, Megin ; Petit, Sue ; Reingold, Arthur ; Schaffner, William ; Thomas, Ann ; Pondo, Tracy ; Mayer, Leonard W ; Clark, Thomas A ; Cohn, Amanda C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c489t-2584b9f744e0e45f59b91f819775e77afee75e6f4797beae3da235c4f88a8a183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Analysis</topic><topic>Babies</topic><topic>Care and treatment</topic><topic>Data collection</topic><topic>Dosage and administration</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Haemophilus influenzae</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Incidence</topic><topic>Infant</topic><topic>Infants</topic><topic>Male</topic><topic>Meningitis</topic><topic>Meningitis, Meningococcal - epidemiology</topic><topic>Meningitis, Meningococcal - microbiology</topic><topic>Meningitis, Meningococcal - prevention & control</topic><topic>Meningococcal infections</topic><topic>Meningococcal Vaccines - administration & dosage</topic><topic>Neisseria meningitidis</topic><topic>Neisseria meningitidis, Serogroup B - pathogenicity</topic><topic>Neisseria meningitidis, Serogroup Y - pathogenicity</topic><topic>Pediatrics</topic><topic>Pneumococcal vaccine</topic><topic>Pneumococcal vaccines</topic><topic>Population Surveillance</topic><topic>Risk factors</topic><topic>Streptococcus pneumoniae</topic><topic>Survival Rate</topic><topic>United States</topic><topic>Vaccines</topic><topic>Virulence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MacNeil, Jessica R</creatorcontrib><creatorcontrib>Bennett, Nancy</creatorcontrib><creatorcontrib>Farley, Monica M</creatorcontrib><creatorcontrib>Harrison, Lee H</creatorcontrib><creatorcontrib>Lynfield, Ruth</creatorcontrib><creatorcontrib>Nichols, Megin</creatorcontrib><creatorcontrib>Petit, Sue</creatorcontrib><creatorcontrib>Reingold, Arthur</creatorcontrib><creatorcontrib>Schaffner, William</creatorcontrib><creatorcontrib>Thomas, Ann</creatorcontrib><creatorcontrib>Pondo, Tracy</creatorcontrib><creatorcontrib>Mayer, Leonard W</creatorcontrib><creatorcontrib>Clark, Thomas A</creatorcontrib><creatorcontrib>Cohn, Amanda C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pediatrics (Evanston)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MacNeil, Jessica R</au><au>Bennett, Nancy</au><au>Farley, Monica M</au><au>Harrison, Lee H</au><au>Lynfield, Ruth</au><au>Nichols, Megin</au><au>Petit, Sue</au><au>Reingold, Arthur</au><au>Schaffner, William</au><au>Thomas, Ann</au><au>Pondo, Tracy</au><au>Mayer, Leonard W</au><au>Clark, Thomas A</au><au>Cohn, Amanda C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epidemiology of infant meningococcal disease in the United States, 2006-2012</atitle><jtitle>Pediatrics (Evanston)</jtitle><addtitle>Pediatrics</addtitle><date>2015-02-01</date><risdate>2015</risdate><volume>135</volume><issue>2</issue><spage>e305</spage><epage>e311</epage><pages>e305-e311</pages><issn>0031-4005</issn><eissn>1098-4275</eissn><coden>PEDIAU</coden><abstract>The incidence of meningococcal disease is currently at historic lows in the United States; however, incidence remains highest among infants aged <1 year. With routine use of Haemophilus influenzae type b and pneumococcal vaccines in infants and children in the United States, Neisseria meningitidis remains an important cause of bacterial meningitis in young children.
Data were collected from active, population- and laboratory-based surveillance for N meningitidis conducted through Active Bacterial Core surveillance during 2006 through 2012. Expanded data collection forms were completed for infant cases identified in the surveillance area during 2006 through 2010.
An estimated 113 cases of culture-confirmed meningococcal disease occurred annually among infants aged <1 year in the United States from 2006 through 2012, for an overall incidence of 2.74 per 100,000 infants. Among these cases, an estimated 6 deaths occurred. Serogroup B was responsible for 64%, serogroup C for 12%, and serogroup Y for 16% of infant cases. Based on the expanded data collection forms, a high proportion of infant cases (36/58, 62%) had a smoker in the household and the socioeconomic status of the census tracts where infant meningococcal cases resided was lower compared with the other Active Bacterial Core surveillance areas and the United States as a whole.
The burden of meningococcal disease remains highest in young infants and serogroup B predominates. Vaccines that provide long-term protection early in life have the potential to reduce the burden of meningococcal disease, especially if they provide protection against serogroup B meningococcal disease.</abstract><cop>United States</cop><pub>American Academy of Pediatrics</pub><pmid>25583921</pmid><doi>10.1542/peds.2014-2035</doi><oa>free_for_read</oa></addata></record> |
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| ispartof | Pediatrics (Evanston), 2015-02, Vol.135 (2), p.e305-e311 |
| issn | 0031-4005 1098-4275 |
| language | eng |
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| source | EZB-FREE-00999 freely available EZB journals |
| subjects | Analysis Babies Care and treatment Data collection Dosage and administration Epidemiology Female Haemophilus influenzae Health aspects Humans Incidence Infant Infants Male Meningitis Meningitis, Meningococcal - epidemiology Meningitis, Meningococcal - microbiology Meningitis, Meningococcal - prevention & control Meningococcal infections Meningococcal Vaccines - administration & dosage Neisseria meningitidis Neisseria meningitidis, Serogroup B - pathogenicity Neisseria meningitidis, Serogroup Y - pathogenicity Pediatrics Pneumococcal vaccine Pneumococcal vaccines Population Surveillance Risk factors Streptococcus pneumoniae Survival Rate United States Vaccines Virulence |
| title | Epidemiology of infant meningococcal disease in the United States, 2006-2012 |
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