Can Free Water Transport be Used as a Clinical Parameter for Peritoneal Fibrosis in Long-Term PD Patients?

Sodium sieving in peritoneal dialysis (PD) occurs in a situation with high osmotically-driven ultrafiltration rates. This dilutional phenomenon is caused by free water transport through the water channel aquaporin-1. It has recently been described that encapsulating peritoneal fibrosis is associated...

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Bibliographic Details
Published in:Peritoneal Dialysis International 2016-03, Vol.36 (2), p.124-128
Main Authors: Krediet, Raymond T., Barreto, Deirisa Lopes, Struijk, Dirk G.
Format: Article
Language:English
Subjects:
Review
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Summary:Sodium sieving in peritoneal dialysis (PD) occurs in a situation with high osmotically-driven ultrafiltration rates. This dilutional phenomenon is caused by free water transport through the water channel aquaporin-1. It has recently been described that encapsulating peritoneal fibrosis is associated with impaired free water transport, despite normal expression of aquaporin-1. In this review, it will be argued that free water transport can be used for assessment of fibrotic peritoneal alterations, due to the water-binding capacity of collagen. Finally, the consequences for clinical practice will be discussed.
ISSN:0896-8608
1718-4304
DOI:10.3747/pdi.2015.00129