A new Bayesian model applied to cytogenetic partial body irradiation estimation

A new zero-inflated Poisson model is introduced for the estimation of partial body irradiation dose and fraction of body irradiated. The Bayes factors are introduced as tools to help determine whether a data set of chromosomal aberrations obtained from a blood sample reflects partial or whole body i...

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Bibliographic Details
Published in:Radiation protection dosimetry 2016-03, Vol.168 (3), p.330-336
Main Authors: Higueras, Manuel, Puig, Pedro, Ainsbury, Elizabeth A, Vinnikov, Volodymyr A, Rothkamm, Kai
Format: Article
Language:English
Subjects:
Bayes Theorem
Bone Marrow Transplantation
Cell Survival - genetics
Cell Survival - radiation effects
Cytogenetic Analysis - methods
Humans
Organs at Risk - radiation effects
Radiation Dosage
Radiometry - methods
Whole-Body Irradiation
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Summary:A new zero-inflated Poisson model is introduced for the estimation of partial body irradiation dose and fraction of body irradiated. The Bayes factors are introduced as tools to help determine whether a data set of chromosomal aberrations obtained from a blood sample reflects partial or whole body irradiation. Two examples of simulated cytogenetic radiation exposure data are presented to demonstrate the usefulness of this methodology in cytogenetic biological dosimetry.
ISSN:0144-8420
1742-3406
DOI:10.1093/rpd/ncv356