Sesame Lignans and Vitamin E Supplementation Improve Subjective Statuses and Anti-Oxidative Capacity in Healthy Humans With Feelings of Daily Fatigue

Sesamin has anti-oxidative functions in vivo. Fatigue is caused in part by oxidative stress. We evaluated whether sesame lignans (sesamin/episesamin=1/1, 10 mg) with vitamin E (55 mg of alpha-tocopherol) (SVE) could improve subjective statuses and anti-oxidative capacity in humans using questionnair...

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Bibliographic Details
Published in:Global journal of health science 2015-03, Vol.7 (6), p.1-10
Main Authors: Takemoto, Daisuke, Yasutake, Yoko, Tomimori, Namino, Ono, Yoshiko, Shibata, Hiroshi, Hayashi, Junichi
Format: Article
Language:English
Subjects:
Adult
Antioxidants - therapeutic use
Double-Blind Method
Fatigue - drug therapy
Female
Humans
Lignans - therapeutic use
Male
Oxidative Stress
Sesamum
Surveys and Questionnaires
Treatment Outcome
Vitamin E - therapeutic use
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Summary:Sesamin has anti-oxidative functions in vivo. Fatigue is caused in part by oxidative stress. We evaluated whether sesame lignans (sesamin/episesamin=1/1, 10 mg) with vitamin E (55 mg of alpha-tocopherol) (SVE) could improve subjective statuses and anti-oxidative capacity in humans using questionnaires on fatigue, sleep and physical appearance, as well as low-density lipoprotein oxidation lag time. A placebo-controlled, double-blind, parallel-group study was conducted with subjects experiencing daily fatigue. After a run-in period, subjects were administered oral SVE or a placebo (P) for 8 weeks. A questionnaire regarding fatigue, sleep and physical appearance was conducted at 0, 4, and 8 weeks. Plasma low-density lipoprotein oxidation lag time was measured as an indicator of anti-oxidative capacity. The per-protocol analysis revealed significant improvements in fatigue status at 4 and 8 weeks compared to 0 weeks in both groups (p
ISSN:1916-9736
1916-9744
DOI:10.5539/gjhs.v7n6p1