Cardiac Function in Newborns with Congenital Hypothyroidism: Association with Thyroid-Stimulating Hormone Levels

• Published in: Journal of clinical research in pediatric endocrinology 2015-12, Vol.7 (4), p.307-311
• Main Authors: Öner, Taliha, Özdemir, Rahmi, Doksöz, Önder, Yozgat, Yılmaz, Karadeniz, Cem, Demirpençe, Savaş, Yılmazer, Murat Muhtar, Büyükinan, Muammer, Meşe, Timur, Tavlı, Vedide
• Format: Article
• Language: English
• Subjects: Congenital Hypothyroidism - blood; Congenital Hypothyroidism - diagnostic imaging; Heart Function Tests; Heart Rate - physiology; Humans; Infant, Newborn; Infant, Newborn, Diseases; Original; Thyrotropin - blood; Ultrasonography; Ventricular Function, Left - physiology
• ISSN: 1308-5727; 1308-5735
• DOI: 10.4274/jcrpe.1969

The aims of this study were to demonstrate ventricular function changes in patients with congenital hypothyroidism and to investigate whether there is an association between any such changes and thyroid-stimulating hormone (TSH) levels using M-mode and Doppler electrocardiography (ECG) and tissue Doppler imaging (TDI). Twenty-seven patients 5-30 days of age with congenital hypothyroidism who were scheduled to receive L-thyroxine treatment and 20 healthy newborns were included in this study. Twelve-lead ECG and M-mode TDI recordings of the patient and healthy groups were obtained. The patient group was divided into two subgroups according to TSH level (>100 uIU/mL or 100 uIU/mL and 100 group. Impairment in left ventricular systolic function and increased risk of arrhythmia were observed in newborn infants with congenital hypothyroidism. TSH level was associated with heart rate and interventricular septum velocity.