NHC-Pd(II) Catalyzed Methylene C(sp3)–H Arylation of Piperidines and Tetrahydropyrans

Pd(II)-catalyzed C(sp 3 )–H arylation of saturated heterocycles with a wide range of aryl iodides has been achieved using a N -heterocyclic carbene (NHC) ligand, thus demonstrating the compatibility of carbene ligands in a Pd(II)/Pd(IV) catalytic manifold. This arylation method provides a new approa...

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Bibliographic Details
Published in:Chemistry : a European journal 2016-02, Vol.22 (14), p.4748-4752
Main Authors: Ye, Shengqing, Yang, Weibo, Coon, Timothy, Fanning, Dewey, Neubert, Tim, Stamos, Dean, Yu, Jin-Quan
Format: Article
Language:English
Online Access:Get full text
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Summary:Pd(II)-catalyzed C(sp 3 )–H arylation of saturated heterocycles with a wide range of aryl iodides has been achieved using a N -heterocyclic carbene (NHC) ligand, thus demonstrating the compatibility of carbene ligands in a Pd(II)/Pd(IV) catalytic manifold. This arylation method provides a new approach towards further diversifying pharmaceutically relevant piperidine and tetrahydropyran ring systems.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201600191