Specification and function of hemogenic endothelium during embryogenesis

Hemogenic endothelium is a specialized subset of developing vascular endothelium that acquires hematopoietic potential and can give rise to multilineage hematopoietic stem and progenitor cells during a narrow developmental window in tissues such as the extraembryonic yolk sac and embryonic aorta-gon...

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Bibliographic Details
Published in:Cellular and molecular life sciences : CMLS 2016-04, Vol.73 (8), p.1547-1567
Main Authors: Gritz, Emily, Hirschi, Karen K.
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cellular biology
Developmental biology
embryogenesis
Embryonic Development
Embryonic growth stage
Embryos
endothelial cells
Endothelium
Endothelium, Vascular - embryology
Hemangioblasts - cytology
Hematopoiesis - physiology
Hematopoietic Stem Cells - cytology
Humans
Life Sciences
Review
Signal Transduction - physiology
stem cells
translation (genetics)
Tretinoin - metabolism
yolk sac
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Summary:Hemogenic endothelium is a specialized subset of developing vascular endothelium that acquires hematopoietic potential and can give rise to multilineage hematopoietic stem and progenitor cells during a narrow developmental window in tissues such as the extraembryonic yolk sac and embryonic aorta-gonad-mesonephros. Herein, we review current knowledge about the historical and developmental origins of hemogenic endothelium, the molecular events that govern hemogenic specification of vascular endothelial cells, the generation of multilineage hematopoietic stem and progenitor cells from hemogenic endothelium, and the potential for translational applications of knowledge gained from further study of these processes.
ISSN:1420-682X
1420-9071
DOI:10.1007/s00018-016-2134-0