The BDNF Val66Met polymorphism is associated with the functional connectivity dynamics of pain modulatory systems in primary dysmenorrhea

Primary dysmenorrhea (PDM), menstrual pain without an organic cause, is a prevailing problem in women of reproductive age. We previously reported alterations of structure and functional connectivity (FC) in the periaqueductal gray (PAG) of PDM subjects. Given that the brain derived neurotrophic fact...

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Published in:Scientific reports 2016-03, Vol.6 (1), p.23639-23639, Article 23639
Main Authors: Wei, Shyh-Yuh, Chao, Hsiang-Tai, Tu, Cheng-Hao, Lin, Ming-Wei, Li, Wei-Chi, Low, Intan, Shen, Horng-Der, Chen, Li-Fen, Hsieh, Jen-Chuen
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Language:English
Subjects:
45/77
59/57
631/378/1689/2610
631/378/2583
692/1807/410/2610
692/420/2489/144
Adult
Brain Mapping
Brain-derived neurotrophic factor
Brain-Derived Neurotrophic Factor - genetics
Chronic pain
Dysmenorrhea - physiopathology
Female
Functional magnetic resonance imaging
Gene polymorphism
Genotyping
Humanities and Social Sciences
Humans
Menstruation
Methionine - genetics
multidisciplinary
Neural networks
Neuroimaging
Pain
Pain - physiopathology
Periaqueductal gray area
Polymorphism, Single Nucleotide
Science
Science (multidisciplinary)
Single-nucleotide polymorphism
Valine - genetics
Young Adult
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creator Wei, Shyh-Yuh
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Hsieh, Jen-Chuen
description Primary dysmenorrhea (PDM), menstrual pain without an organic cause, is a prevailing problem in women of reproductive age. We previously reported alterations of structure and functional connectivity (FC) in the periaqueductal gray (PAG) of PDM subjects. Given that the brain derived neurotrophic factor (BDNF) acts as a pain modulator within the PAG and the BDNF Val66Met polymorphism contributes towards susceptibility to PDM, the present study of imaging genetics set out to investigate the influence of, firstly, the BDNF Val66Met single nucleotide polymorphism and, secondly, the genotype-pain interplays on the descending pain modulatory systems in the context of PAG-seeded FC patterning. Fifty-six subjects with PDM and 60 controls participated in the current study of resting-state functional magnetic resonance imaging (fMRI) during the menstruation and peri-ovulatory phases; in parallel, blood samples were taken for genotyping. Our findings indicate that the BDNF Val66Met polymorphism is associated with the diverse functional expressions of the descending pain modulatory systems. Furthermore, PAG FC patterns in pain-free controls are altered in women with PDM in a genotype-specific manner. Such resilient brain dynamics may underpin the individual differences and shed light on the vulnerability for chronic pain disorders of PDM subjects.
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subjects 45/77
59/57
631/378/1689/2610
631/378/2583
692/1807/410/2610
692/420/2489/144
Adult
Brain Mapping
Brain-derived neurotrophic factor
Brain-Derived Neurotrophic Factor - genetics
Chronic pain
Dysmenorrhea - physiopathology
Female
Functional magnetic resonance imaging
Gene polymorphism
Genotyping
Humanities and Social Sciences
Humans
Menstruation
Methionine - genetics
multidisciplinary
Neural networks
Neuroimaging
Pain
Pain - physiopathology
Periaqueductal gray area
Polymorphism, Single Nucleotide
Science
Science (multidisciplinary)
Single-nucleotide polymorphism
Valine - genetics
Young Adult
title The BDNF Val66Met polymorphism is associated with the functional connectivity dynamics of pain modulatory systems in primary dysmenorrhea
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