Bioresorbable Scaffolds for Atheroregression: Understanding of Transient Scaffolding

This review focuses on the clinical and biological features of the bioresorbable scaffolds in interventional cardiology highlighting scientific achievements and challenges of the transient scaffolding with Absorb BVS. Special attention is granted to the vascular biology pathways which, involved in t...

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Bibliographic Details
Published in:Current cardiology reviews 2016-01, Vol.12 (1), p.66-82
Main Author: Kharlamov, Alexander N
Format: Article
Language:English
Subjects:
Absorbable Implants
Animals
Arteries
Atherosclerosis - surgery
Clinical Trials as Topic
Humans
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Summary:This review focuses on the clinical and biological features of the bioresorbable scaffolds in interventional cardiology highlighting scientific achievements and challenges of the transient scaffolding with Absorb BVS. Special attention is granted to the vascular biology pathways which, involved in the resorption of scaffold, artery remodeling and mechanisms of Glagovian atheroregression setting the stage for subsequent clinical applications. Twenty five years ago Glagov described the phenomenon of limited external elastic membrane enlargement in response to an increase in plaque burden. We believe this threshold becomes the target for development of strategies that reverse atherosclerosis, and particularly transient scaffolding has a potential to be a tool to ultimately conquer atherosclerosis.
ISSN:1573-403X
1875-6557
DOI:10.2174/1573403X1201160126125853