Selective Conditions for a Multidrug Resistance Plasmid Depend on the Sociality of Antibiotic Resistance

Multidrug resistance (MDR) plasmids frequently carry antibiotic resistance genes conferring qualitatively different mechanisms of resistance. We show here that the antibiotic concentrations selecting for the RK2 plasmid inEscherichia colidepend upon the sociality of the drug resistance: the selectio...

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Bibliographic Details
Published in:Antimicrobial agents and chemotherapy 2016-04, Vol.60 (4), p.2524-2527
Main Authors: Bottery, Michael J, Wood, A Jamie, Brockhurst, Michael A
Format: Article
Language:English
Subjects:
Adaptation, Physiological
Ampicillin - pharmacology
Anti-Bacterial Agents
Anti-Bacterial Agents - pharmacology
beta-Lactamases
beta-Lactamases - genetics
beta-Lactamases - metabolism
Drug Resistance, Multiple, Bacterial
Drug Resistance, Multiple, Bacterial - genetics
Escherichia coli
Escherichia coli - drug effects
Escherichia coli - enzymology
Escherichia coli - genetics
Gene Expression
Microbial Sensitivity Tests
Plasmids
Plasmids - chemistry
Plasmids - metabolism
Selection, Genetic
Susceptibility
Tetracycline - pharmacology
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Summary:Multidrug resistance (MDR) plasmids frequently carry antibiotic resistance genes conferring qualitatively different mechanisms of resistance. We show here that the antibiotic concentrations selecting for the RK2 plasmid inEscherichia colidepend upon the sociality of the drug resistance: the selection for selfish drug resistance (efflux pump) occurred at very low drug concentrations, just 1.3% of the MIC of the plasmid-free antibiotic-sensitive strain, whereas selection for cooperative drug resistance (modifying enzyme) occurred at drug concentrations exceeding the MIC of the plasmid-free strain.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.02441-15