Toxicity of Smokeless Tobacco Extract after 184-Day Repeated Oral Administration in Rats

The use of smokeless tobacco (ST) is growing rapidly and globally. The consumption of ST is associated with an increased risk for developing chronic diseases, such as diabetes, hypercholesterolemia, and myocardial infarction, and has led to many public health problems. It is very important to access...

Full description

Saved in:
Bibliographic Details
Published in:International journal of environmental research and public health 2016-03, Vol.13 (3), p.281-1
Main Authors: Yu, Chenlin, Zhang, Ziteng, Liu, Yangang, Zong, Ying, Chen, Yongchun, Du, Xiuming, Chen, Jikuai, Feng, Shijie, Hu, Jinlian, Cui, Shufang, Lu, Guocai
Format: Article
Language:English
Subjects:
Administration, Oral
Adults
Animals
Body weight
China
Chronic effects
Diabetes mellitus
Esophagus
Female
Females
Health problems
Health risks
Hematology
Histopathology
Hypercholesterolemia
Kidney - drug effects
Laboratory animals
Liver
Liver - drug effects
Lungs
Male
Mortality
Myocardial infarction
Nicotine
Nicotine - blood
Nicotine - toxicity
Oral administration
Organ Size - drug effects
Plant Extracts - blood
Plant Extracts - toxicity
Public health
Rats
Rats, Sprague-Dawley
Rodents
Stomach
Tobacco
Tobacco, Smokeless - toxicity
Toxicity
Toxicology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The use of smokeless tobacco (ST) is growing rapidly and globally. The consumption of ST is associated with an increased risk for developing chronic diseases, such as diabetes, hypercholesterolemia, and myocardial infarction, and has led to many public health problems. It is very important to access the toxicity of ST. This experiment presents data from 184-day toxicology studies in Sprague-Dawley (SD) rats designed to characterize the chronic effects of a smokeless tobacco extract (STE). The control group and treatment groups were matched for a range of nicotine levels. Animals were given STE by oral gavage with doses of 3.75 (low-dose), 7.50 (mid-dose) and 15.00 (high-dose) mg · nicotine/kg body weight/day for 184 days, followed by 30 days for recovery. Variables evaluated included body weights, feed consumption, clinical observations, clinical and anatomic pathology (including organ weights), and histopathology. Decreased body weights and organ weights (heart, liver and kidney) were found in animals in the mid-dose and high-dose groups. STE also showed moderate and reversible toxicity in esophagus, stomach, liver, kidney and lung.
ISSN:1660-4601
1661-7827
1660-4601
DOI:10.3390/ijerph13030281