Obesity and Cancer: Concepts and Challenges

The rates of overweight and obesity are increasing worldwide in both developed and developing countries. Obesity is a major public health problem as it is associated with many diseases, including diabetes, hypertension, dyslipidemia, atherosclerosis, and some types of cancer. Breast cancer is a mali...

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Bibliographic Details
Published in:Indian journal of surgical oncology 2015-12, Vol.6 (4), p.390-398
Main Authors: Argolo, Daniel F., Iyengar, Neil M., Hudis, Clifford A.
Format: Article
Language:English
Subjects:
Medicine
Medicine & Public Health
Oncology
Review
Review Article
Surgery
Surgical Oncology
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Summary:The rates of overweight and obesity are increasing worldwide in both developed and developing countries. Obesity is a major public health problem as it is associated with many diseases, including diabetes, hypertension, dyslipidemia, atherosclerosis, and some types of cancer. Breast cancer is a malignancy in which both the risk of development and the prognosis are negatively impacted by the obese state. The precise mechanisms pathophysiologically linking obesity and cancer are still under investigation. The biological basis for these associations includes both systemic and local tissue effects and white adipose tissue inflammation appears to be a critical component. A comprehensive understanding of the mechanisms linking obesity, inflammation and cancer may provide an opportunity for the development of strategies to attenuate the negative impact of obesity.
ISSN:0975-7651
0976-6952
DOI:10.1007/s13193-015-0483-z