Significance of alpha smooth muscle actin expression in traumatic painful neuromas: a pilot study in rats

Treatment of painful neuromas remains a challenge and the mechanism of neuroma-associated pain is not yet fully understood. In this study, we aimed to observe the expression of alpha smooth muscle actin (α-SMA) in traumatic neuromas and to investigate its possible roles in the cause of neuropathic p...

Full description

Saved in:
Bibliographic Details
Published in:Scientific reports 2016-03, Vol.6 (1), p.23828-23828, Article 23828
Main Authors: Weng, Weidong, Zhao, Bin, Lin, Dingshen, Gao, Weiyang, Li, Zhijie, Yan, Hede
Format: Article
Language:English
Subjects:
692/699/375/1692
692/699/578
82/1
82/80
Actin
Actins - biosynthesis
Anilides - pharmacology
Animals
Benzamides - pharmacology
Blotting, Western
c-Fos protein
Dioxoles - pharmacology
Disease Models, Animal
Humanities and Social Sciences
Humans
Immunohistochemistry
Mechanical stimuli
multidisciplinary
Neuralgia
Neuralgia - etiology
Neuralgia - metabolism
Neuralgia - physiopathology
Neuroma - metabolism
Neuroma - pathology
Pain
Pilot Projects
Proto-Oncogene Proteins c-fos - metabolism
Rats
Rodents
Sciatic nerve
Sciatic Nerve - metabolism
Sciatic Nerve - physiopathology
Sciatic Neuropathy - metabolism
Sciatic Neuropathy - physiopathology
Science
Smooth muscle
Spinal Cord - drug effects
Spinal Cord - metabolism
Spinal Cord Dorsal Horn - drug effects
Spinal Cord Dorsal Horn - metabolism
Wounds and Injuries - complications
Wounds and Injuries - physiopathology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Treatment of painful neuromas remains a challenge and the mechanism of neuroma-associated pain is not yet fully understood. In this study, we aimed to observe the expression of alpha smooth muscle actin (α-SMA) in traumatic neuromas and to investigate its possible roles in the cause of neuropathic pain in a rat model. The rat sciatic nerve was used and the experiment was divided into two parts. In part I, our results showed significantly higher levels of α-SMA and the pain marker c-fos in the autotomy group than in the no-autotomy group. In part II, the expression of α-SMA in neuromas was down- and up-regulated using SB-431542 and GW9662, respectively. A significant correlation between autotomy scores and the expression level of α-SMA was found (R = 0.957; p 
ISSN:2045-2322
2045-2322
DOI:10.1038/srep23828