Myocardial injury after phenylpropanolamine ingestion

Three patients developed clinical evidence of myocardial injury after acute ingestion of phenylpropanolamine, a sympathomimetic amine found in a large number of decongestant and appetite suppressant formulations. Increases in the serum creatine kinase and MB isoenzyme levels, ventricular arrhythmias...

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Bibliographic Details
Published in:British Heart Journal 1982-01, Vol.47 (1), p.51-54
Main Authors: Pentel, P R, Mikell, F L, Zavoral, J H
Format: Article
Language:English
Subjects:
Adolescent
Adult
Creatine Kinase - blood
Electrocardiography
Female
Heart Diseases - chemically induced
Heart Diseases - physiopathology
Humans
Isoenzymes
Phenylpropanolamine - adverse effects
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Summary:Three patients developed clinical evidence of myocardial injury after acute ingestion of phenylpropanolamine, a sympathomimetic amine found in a large number of decongestant and appetite suppressant formulations. Increases in the serum creatine kinase and MB isoenzyme levels, ventricular arrhythmias, and electrocardiographic repolarisation abnormalities were seen. Excessive catecholamine stimulation has been shown to produce acute myocardial necrosis experimentally, and a similar mechanism may be present in these patients.
ISSN:0007-0769
1355-6037
1468-201X
2053-5864
DOI:10.1136/hrt.47.1.51