Secondary B-cell lymphoma diagnosed by fine-needle aspiration cytology and flow cytometry following penile carcinoma: A case report

The number of studies reporting lymphoma as a secondary tumor has gradually increased. However, few studies have reported that occurrence of lymphoma as a secondary tumor following treatment for penile carcinoma, particularly cases in which the lymphoma was diagnosed by fine-needle aspiration cytolo...

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Bibliographic Details
Published in:Oncology letters 2016-04, Vol.11 (4), p.2449-2452
Main Authors: WANG, HUAN, QIU, LIAN-NV, WU, MAO, CHEN, WAN-YUAN, REN, LI-GANG, HE, XIANG-LEI, ZHOU, YONG-LIE
Format: Article
Language:English
Subjects:
Biopsy
Cancer therapies
Care and treatment
Case reports
Case studies
Cellular biology
Diagnosis
fine-needle aspiration biopsy
Flow cytometry
Genital cancers
Laboratories
Lymphatic system
Lymphoma
Lymphomas
Medical diagnosis
Mortality
Oncology
Patients
penile carcinoma
Penis
Tumors
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Summary:The number of studies reporting lymphoma as a secondary tumor has gradually increased. However, few studies have reported that occurrence of lymphoma as a secondary tumor following treatment for penile carcinoma, particularly cases in which the lymphoma was diagnosed by fine-needle aspiration cytology and flow cytometry. The present study reports the case of a 62-year-old male patient who was troubled with frequent urination and repeated chest tightness for 5 years. The diagnosis upon admission was penile carcinoma. Two months subsequent to the tumor removal surgery, enlarged lymph nodes were extracted from the patient using fine-needle biopsy, to be analyzed using light microscopy and flow cytometry. Smear results indicated a large number of abnormal cells scattered in the right axillary lymph node. Flow cytometry immunophenotyping of fine-needle aspiration samples indicated the increased expression of cluster of differentiation (CD)79a, CD19, CD20, CD38, κ chain and human leukocyte antigen-DR, which supported a diagnosis of B-cell lymphoma. Thus, the patient was diagnosed with B-cell lymphoma based on the results of the fine-needle aspiration biopsy and flow cytometry. The method of diagnosis and causes of therapy-related leukemia are discussed in the present report.
ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2016.4279