AMPK, a key regulator of metabolic/energy homeostasis and mitochondrial biogenesis in cancer cells

In a recent study published in Cell Death and Discovery, it has been shown that energy homeostasis and adaptation to metabolic stress in cancer cells are primarily achieved by integrated response exerted by activation of an energy sensor, AMPK.3 The study provides evidence that the AMPK-p38-PGC1-α a...

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Bibliographic Details
Published in:Cell death & disease 2016-01, Vol.7 (1), p.e2044-e2044
Main Authors: Chaube, B, Bhat, M K
Format: Article
Language:English
Subjects:
631/443/319/1557
631/80/86
692/699/67/327
AMP-Activated Protein Kinases - metabolism
and
Antibodies
Biochemistry
Biomedical and Life Sciences
Biosynthesis
Cancer
Cell Biology
Cell Culture
Cellular biology
Homeostasis
Homeostasis - physiology
Humans
Immunology
Life Sciences
Mitochondria
Neoplasms - metabolism
news-and-commentary
Organelle Biogenesis
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Description
Summary:In a recent study published in Cell Death and Discovery, it has been shown that energy homeostasis and adaptation to metabolic stress in cancer cells are primarily achieved by integrated response exerted by activation of an energy sensor, AMPK.3 The study provides evidence that the AMPK-p38-PGC1-α axis, by increasing mitochondrial biogenesis, supports oxidative metabolism of non-glucose substrates to maintain the cellular ATP pool. This study highlights the fundamental role of AMPK in maintaining energy and metabolic homeostasis, and in promoting cell survival under glucose-limiting condition.
ISSN:2041-4889
2041-4889
DOI:10.1038/cddis.2015.404