Two cases of cisplatin-induced permanent renal failure following neoadjuvant chemotherapy for esophageal cancer

Highlights • Two esophageal cancer patients developed severe acute renal failure after neoadjuvant chemotherapy with cisplatin and 5-fluorourasil. • Volume expansion remains the most effective strategy for prevention of cisplatin nephrotoxicity. • The two patients described here received sufficient...

Full description

Saved in:
Bibliographic Details
Published in:International journal of surgery case reports 2016-01, Vol.20, p.63-67
Main Authors: Sasaki, Tomohiko, Motoyama, Satoru, Komatsuda, Atsushi, Shibata, Hiroyuki, Sato, Yusuke, Yoshino, Kei, Wakita, Akiyuki, Saito, Hajime, Anbai, Akira, Jin, Mario, Minamiya, Yoshihiro
Format: Article
Language:English
Subjects:
Case Report
Cisplatin
Esophageal cancer
Neoadjuvant chemotherapy
Renal failure
Surgery
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights • Two esophageal cancer patients developed severe acute renal failure after neoadjuvant chemotherapy with cisplatin and 5-fluorourasil. • Volume expansion remains the most effective strategy for prevention of cisplatin nephrotoxicity. • The two patients described here received sufficient drip infusion and produced good urine volumes. • In both cases, renal biopsy examination indicated partial recovery of the proximal tubule, but renal function did not recover.
ISSN:2210-2612
2210-2612
DOI:10.1016/j.ijscr.2016.01.009