Mitochondria and senescence: new actors for an old play

Mitochondrial dysfunction has been linked to both cellular senescence and ageing. Despite the relationship, it is still unclear whether mitochondria have a causal role in senescence. In this issue of The EMBO   Journal , Correia‐Melo et al ( 2016 ) combine targeted depletion of mitochondria with imp...

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Bibliographic Details
Published in:The EMBO journal 2016-04, Vol.35 (7), p.701-702
Main Authors: Herranz, Nicolás, Gil, Jesús
Format: Article
Language:English
Subjects:
Aging
Aging - physiology
Animals
Cellular biology
EMBO01
EMBO06
EMBO21
Humans
Mitochondria
Mitochondria - physiology
News & Views
Senescence
Views
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Summary:Mitochondrial dysfunction has been linked to both cellular senescence and ageing. Despite the relationship, it is still unclear whether mitochondria have a causal role in senescence. In this issue of The EMBO   Journal , Correia‐Melo et al ( 2016 ) combine targeted depletion of mitochondria with impairment of their biogenesis to demonstrate that decreased numbers of mitochondria impair the senescence response. Their results suggest that targeting mitochondria could reduce the detrimental effects of senescence during ageing. Graphical Abstract A new study reveals a causal role of mitochondria for cellular senescence phenotypes and ageing.
ISSN:0261-4189
1460-2075
1460-2075
DOI:10.15252/embj.201694025