Simvastatin-induced cognitive dysfunction: two case reports

Simvastatin is commonly prescribed for hypercholesterolemia to reduce vascular risk in patients. Some of these patients have dementia with cognitive defects of several domains. Although protective effects seem to be present, there is emerging evidence that statins cause cognitive impairment. The rol...

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Bibliographic Details
Published in:Journal of medical case reports 2016-04, Vol.10 (83), p.83-83, Article 83
Main Authors: Suraweera, Chathurie, de Silva, Varuni, Hanwella, Raveen
Format: Article
Language:English
Subjects:
Adult
Bipolar disorder
Care and treatment
Case Report
Cholesterol
Cognition disorders
Cognitive ability
Cognitive Dysfunction - chemically induced
Complications and side effects
Dementia
Development and progression
Female
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects
Hypercholesterolemia - drug therapy
Male
Medical imaging
Memory
Memory Disorders - chemically induced
Mental disorders
Middle Aged
NMR
Nuclear magnetic resonance
Quality of life
Simvastatin
Simvastatin - adverse effects
Statins
Studies
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Summary:Simvastatin is commonly prescribed for hypercholesterolemia to reduce vascular risk in patients. Some of these patients have dementia with cognitive defects of several domains. Although protective effects seem to be present, there is emerging evidence that statins cause cognitive impairment. The role of cholesterol in cognitive function is complex. This is reflected in the effects that statins show on cognition functions. The reduction in cholesterol levels seen with statins is effective in improving learning and memory in some patients. However, there is emerging evidence that statins may worsen cognitive function. Similarly, there are major concerns over whether statins alleviate or worsen cognitive problems. The correlation between cholesterol levels and cognitive function is still controversial, mainly due to a lack of robust evidence. We report the cases of two Asian patients who developed cognitive deficits after starting simvastatin. A 32-year-old man and a 54-year-old woman developed different but clear cognitive deficits that reversed after stopping simvastatin. The possibility of new-onset cognitive dysfunction and the deterioration of existing cognitive deficits should be considered when prescribing simvastatin to patients.
ISSN:1752-1947
1752-1947
DOI:10.1186/s13256-016-0877-8