Intermuscular adipose tissue is associated with monocyte chemoattractant protein-1, independent of visceral adipose tissue

Emerging evidence suggests that intermuscular adipose tissue is a risk factor for insulin resistance, but the underlying mechanism still remains unclear. We investigated whether the levels of leptin, adiponectin, and monocyte chemoattractant protein-1 are associated with intermuscular adipose tissue...

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Published in:Clinical biochemistry 2016-04, Vol.49 (6), p.439-443
Main Authors: Haam, Ji-Hee, Kim, Young-Sang, Koo, Hyung Suk, Haam, Juhee, Seo, Nam Kyoung, Kim, Hyung Yuk, Park, Kyung-Chae, Park, Kye-Seon, Kim, Moon Jong
Format: Article
Language:English
Subjects:
Adiponectin
Adiponectin - metabolism
Adipose Tissue - metabolism
Adult
Chemokine CCL2 - metabolism
Cross-Sectional Studies
Enzyme-Linked Immunosorbent Assay
Female
Humans
Intermuscular adipose tissue
Intra-Abdominal Fat - metabolism
Leptin
Leptin - metabolism
MCP-1
Middle Aged
Muscles - metabolism
Obesity
Obesity - metabolism
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Summary:Emerging evidence suggests that intermuscular adipose tissue is a risk factor for insulin resistance, but the underlying mechanism still remains unclear. We investigated whether the levels of leptin, adiponectin, and monocyte chemoattractant protein-1 are associated with intermuscular adipose tissue in obese subjects. A cross-sectional study was performed on 77 obese Korean women. Areas of visceral adipose tissue, subcutaneous adipose tissue, and intermuscular adipose tissue were measured by computed tomography scan, and serum concentrations of adipokines were measured by enzyme-linked immunosorbent assays. Correlation between the levels of adipokines and the fat areas was assessed using Pearson correlation and covariate-adjusted multivariable regression. Leptin was positively correlated with subcutaneous adipose tissue (r=0.452, P
ISSN:0009-9120
1873-2933
DOI:10.1016/j.clinbiochem.2015.12.003