NGF FLIPs TrkA onto the death TRAIL in neuroblastoma cells

Spatial and temporal changes in the expression of nerve growth factor (NGF) and its receptor tropomyosin-related kinase A (TrkA) are important in regulating cell fate choice as neuroblast delineate from the neural crest, migrate throughout the developing embryo, differentiate along the sympatho-adre...

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Bibliographic Details
Published in:Cell death & disease 2016-03, Vol.7 (3), p.e2139-e2139
Main Authors: Ruggeri, P, Cappabianca, L, Farina, A R, Gneo, L, Mackay, A R
Format: Article
Language:English
Subjects:
631/45/607/275
631/67/1922
631/80/82/23
631/80/86
and
Antibodies
Apoptosis
Biochemistry
Biomedical and Life Sciences
Cancer
Cell Biology
Cell Culture
Humans
Immunology
Life Sciences
Neoplasm Proteins - metabolism
Nerve Growth Factor - metabolism
Nervous system
Neuroblastoma - metabolism
Neuroblastoma - pathology
news-and-commentary
Receptor, trkA - metabolism
Signal transduction
TNF-Related Apoptosis-Inducing Ligand - metabolism
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Summary:Spatial and temporal changes in the expression of nerve growth factor (NGF) and its receptor tropomyosin-related kinase A (TrkA) are important in regulating cell fate choice as neuroblast delineate from the neural crest, migrate throughout the developing embryo, differentiate along the sympatho-adrenal lineage and eventually give rise to the sympathetic nervous system (SNS). Within this context, the ligation of active NGF by TrkA protects neuroblasts against apoptosis and promotes differentiation; pro-form NGF, in the absence of TrkA, promotes neuroblast apoptosis via the low-affinity NGF receptor p75NTR and sortilin, and in the absence of NGF, TrkA recruits p75NTR as a hired killer to induce neuroblast apoptosis
ISSN:2041-4889
2041-4889
DOI:10.1038/cddis.2016.49